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The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron
Christine Toelzer, Kapil Gupta, Sathish K.N. Yadav, Lorna Hodgson, Maia Kavanagh Williamson, Dora Buzas, Ufuk Borucu, Kyle Powers, Richard Stenner, Kate Vasileiou, Frederic Garzoni, Daniel Fitzgerald, Christine Payré, Gérard Lambeau, Andrew D. Davidson, View ORCID ProfilePaul Verkade, Martin Frank, Imre Berger, Christiane Schaffitzel
doi: https://doi.org/10.1101/2022.04.22.489083
Christine Toelzer
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Kapil Gupta
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Sathish K.N. Yadav
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Lorna Hodgson
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Maia Kavanagh Williamson
3Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, BS8 1TD, UK
Dora Buzas
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
4Max Planck Bristol Centre for Minimal Biology, Cantock’s Close, Bristol BS8 1TS, UK
Ufuk Borucu
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Kyle Powers
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Richard Stenner
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Kate Vasileiou
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Frederic Garzoni
5Imophoron Ltd, St. Philips Central, Albert Rd, Bristol, BS2 0XJ, UK
Daniel Fitzgerald
6Halo Therapeutics Ltd, St. Philips Central, Albert Rd, Bristol, BS2 0XJ, UK
Christine Payré
7Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France
Gérard Lambeau
7Université Côte d’Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne Sophia Antipolis, France
Andrew D. Davidson
3Cellular and Molecular Medicine, University of Bristol, University Walk, Bristol, BS8 1TD, UK
Paul Verkade
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
Martin Frank
8Biognos AB, Box 8963, 40274 Göteborg, Sweden
Imre Berger
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
4Max Planck Bristol Centre for Minimal Biology, Cantock’s Close, Bristol BS8 1TS, UK
6Halo Therapeutics Ltd, St. Philips Central, Albert Rd, Bristol, BS2 0XJ, UK
9School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK
Christiane Schaffitzel
1School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK
2Bristol Synthetic Biology Centre BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, UK
6Halo Therapeutics Ltd, St. Philips Central, Albert Rd, Bristol, BS2 0XJ, UK
Posted April 22, 2022.
The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron
Christine Toelzer, Kapil Gupta, Sathish K.N. Yadav, Lorna Hodgson, Maia Kavanagh Williamson, Dora Buzas, Ufuk Borucu, Kyle Powers, Richard Stenner, Kate Vasileiou, Frederic Garzoni, Daniel Fitzgerald, Christine Payré, Gérard Lambeau, Andrew D. Davidson, Paul Verkade, Martin Frank, Imre Berger, Christiane Schaffitzel
bioRxiv 2022.04.22.489083; doi: https://doi.org/10.1101/2022.04.22.489083
The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron
Christine Toelzer, Kapil Gupta, Sathish K.N. Yadav, Lorna Hodgson, Maia Kavanagh Williamson, Dora Buzas, Ufuk Borucu, Kyle Powers, Richard Stenner, Kate Vasileiou, Frederic Garzoni, Daniel Fitzgerald, Christine Payré, Gérard Lambeau, Andrew D. Davidson, Paul Verkade, Martin Frank, Imre Berger, Christiane Schaffitzel
bioRxiv 2022.04.22.489083; doi: https://doi.org/10.1101/2022.04.22.489083
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