A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Noriko Iwamoto; Yoshinobu Koguchi; Kotoko Yokoyama; Akinobu Hamada; Atsushi Yonezawa; Brian D. Piening; Eric Tran; Bernard A. Fox; William L. Redmond; Takashi Shimada

doi:10.1101/2022.04.22.489238

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A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Noriko Iwamoto, Yoshinobu Koguchi, Kotoko Yokoyama, Akinobu Hamada, Atsushi Yonezawa, Brian D. Piening, Eric Tran, Bernard A. Fox, William L. Redmond, Takashi Shimada

doi: https://doi.org/10.1101/2022.04.22.489238

Noriko Iwamoto

1Shimadzu Bioscience Research Partnership, Shimadzu Scientific Instruments., 21720 23rd Dr SE, Bothell, WA 98021

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Yoshinobu Koguchi

2Earle A. Chiles Research Institute, Providence Cancer Institute., 4805 NE Glisan St. Portland, OR 97213

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Kotoko Yokoyama

3Global Application Development Center, Shimadzu Corporation., Nishinokyo-Kuwabaracho, Nakagyo-ku, Kyoto 604-8511, Japan

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Akinobu Hamada

4Division of Molecular Pharmacology, National Cancer Center., 5-1-1 Tsukuji, Chuo-ku, Tokyo 104-0045, Japan

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Atsushi Yonezawa

5Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital., 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan

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Brian D. Piening

2Earle A. Chiles Research Institute, Providence Cancer Institute., 4805 NE Glisan St. Portland, OR 97213

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Eric Tran

2Earle A. Chiles Research Institute, Providence Cancer Institute., 4805 NE Glisan St. Portland, OR 97213

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Bernard A. Fox

2Earle A. Chiles Research Institute, Providence Cancer Institute., 4805 NE Glisan St. Portland, OR 97213

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William L. Redmond

2Earle A. Chiles Research Institute, Providence Cancer Institute., 4805 NE Glisan St. Portland, OR 97213

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Takashi Shimada

1Shimadzu Bioscience Research Partnership, Shimadzu Scientific Instruments., 21720 23rd Dr SE, Bothell, WA 98021

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For correspondence: t-shima@shimadzu.co.jp

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Posted April 23, 2022.

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A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Noriko Iwamoto, Yoshinobu Koguchi, Kotoko Yokoyama, Akinobu Hamada, Atsushi Yonezawa, Brian D. Piening, Eric Tran, Bernard A. Fox, William L. Redmond, Takashi Shimada

bioRxiv 2022.04.22.489238; doi: https://doi.org/10.1101/2022.04.22.489238

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A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Noriko Iwamoto, Yoshinobu Koguchi, Kotoko Yokoyama, Akinobu Hamada, Atsushi Yonezawa, Brian D. Piening, Eric Tran, Bernard A. Fox, William L. Redmond, Takashi Shimada

bioRxiv 2022.04.22.489238; doi: https://doi.org/10.1101/2022.04.22.489238

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