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Memory loss at sleep onset

View ORCID ProfileCélia Lacaux, View ORCID ProfileThomas Andrillon, View ORCID ProfileIsabelle Arnulf, View ORCID ProfileDelphine Oudiette
doi: https://doi.org/10.1101/2022.04.25.489361
Célia Lacaux
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS
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  • For correspondence: delphine.oudiette@icm-institute.org celia.lacaux@gmail.com
Thomas Andrillon
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS
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Isabelle Arnulf
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS
2AP-HP, Hôpital Pitié-Salpêtrière, Service des Pathologies du Sommeil, National Reference, Centre for Narcolepsy, Paris, France
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Delphine Oudiette
1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS
2AP-HP, Hôpital Pitié-Salpêtrière, Service des Pathologies du Sommeil, National Reference, Centre for Narcolepsy, Paris, France
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  • For correspondence: delphine.oudiette@icm-institute.org celia.lacaux@gmail.com
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ABSTRACT

Every night, we pass through a transitory zone at the borderland between wakefulness and sleep, named the first stage of non-rapid eye movement sleep (N1). N1 sleep is associated with an increased hippocampal activity and dreamlike experiences that incorporate recent wake materials, suggesting that it may be associated with memory processing. Here, we investigated the specific contribution of N1 sleep in the processing of memory traces. Participants were asked to learn the precise locations of 48 objects on a grid and were then tested on their memory for these items before and after a 30-minute rest during which participants either stayed fully awake, transitioned toward N1 or deeper (N2) sleep. We showed that memory recall was lower (10% forgetting) after a resting period including only N1 sleep compared to N2 sleep. Furthermore, the ratio of alpha/theta power (an EEG marker of the transition towards sleep) correlated negatively with the forgetting rate when taking into account all sleepers (N1 and N2 groups combined), suggesting a physiological index for memory loss that transcends sleep stages. Our findings suggest that interrupting sleep onset at N1 may alter sleep-dependent memory consolidation and promote forgetting.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 25, 2022.
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Memory loss at sleep onset
Célia Lacaux, Thomas Andrillon, Isabelle Arnulf, Delphine Oudiette
bioRxiv 2022.04.25.489361; doi: https://doi.org/10.1101/2022.04.25.489361
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Memory loss at sleep onset
Célia Lacaux, Thomas Andrillon, Isabelle Arnulf, Delphine Oudiette
bioRxiv 2022.04.25.489361; doi: https://doi.org/10.1101/2022.04.25.489361

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