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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

View ORCID ProfileJean-Louis A. Parmasad, View ORCID ProfileKonrad M. Ricke, View ORCID ProfileMorgan G. Stykel, Brodie Buchner-Duby, Eric Lian, View ORCID ProfileBenjamin Nguyen, View ORCID ProfileNathalie A. Lengacher, View ORCID ProfileHaley M. Geertsma, Amanda Bruce, View ORCID ProfileSteve M. Callaghan, View ORCID ProfileAlvin Joselin, View ORCID ProfileJulianna J. Tomlinson, View ORCID ProfileMichael G. Schlossmacher, View ORCID ProfileWilliam L. Stanford, View ORCID ProfilePatrik Brundin, View ORCID ProfileScott D. Ryan, View ORCID ProfileMaxime W.C. Rousseaux
doi: https://doi.org/10.1101/2022.05.02.490309
Jean-Louis A. Parmasad
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
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  • ORCID record for Jean-Louis A. Parmasad
Konrad M. Ricke
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
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Morgan G. Stykel
4Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON
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  • ORCID record for Morgan G. Stykel
Brodie Buchner-Duby
4Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON
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Eric Lian
5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
6Ottawa Institute for Systems Biology, University of Ottawa, Ottawa, ON
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Benjamin Nguyen
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
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Nathalie A. Lengacher
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
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  • ORCID record for Nathalie A. Lengacher
Haley M. Geertsma
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
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Amanda Bruce
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
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Steve M. Callaghan
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
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Alvin Joselin
7Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, AB
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  • ORCID record for Alvin Joselin
Julianna J. Tomlinson
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
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Michael G. Schlossmacher
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
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William L. Stanford
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
6Ottawa Institute for Systems Biology, University of Ottawa, Ottawa, ON
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Patrik Brundin
8Parkinson’s Disease Center, Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI
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Scott D. Ryan
4Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON
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Maxime W.C. Rousseaux
1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
6Ottawa Institute for Systems Biology, University of Ottawa, Ottawa, ON
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  • For correspondence: max.rousseaux@uottawa.ca
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Article Information

doi 
https://doi.org/10.1101/2022.05.02.490309
History 
  • May 2, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Jean-Louis A. Parmasad1,2,†,
  2. Konrad M. Ricke1,2,3,†,
  3. Morgan G. Stykel4,
  4. Brodie Buchner-Duby4,
  5. Eric Lian5,6,
  6. Benjamin Nguyen1,2,3,
  7. Nathalie A. Lengacher1,3,5,
  8. Haley M. Geertsma1,2,3,
  9. Amanda Bruce1,2,
  10. Steve M. Callaghan1,2,3,
  11. Alvin Joselin7,
  12. Julianna J. Tomlinson1,3,5,
  13. Michael G. Schlossmacher1,3,5,
  14. William L. Stanford2,5,6,
  15. Patrik Brundin8,
  16. Scott D. Ryan4 and
  17. Maxime W.C. Rousseaux1,2,3,6,*
  1. 1University of Ottawa Brain and Mind Research Institute, Ottawa, ON
  2. 2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON
  3. 3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
  4. 4Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON
  5. 5Program in Neuroscience, Ottawa Hospital Research Institute, Ottawa, ON
  6. 6Ottawa Institute for Systems Biology, University of Ottawa, Ottawa, ON
  7. 7Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, AB
  8. 8Parkinson’s Disease Center, Department of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI
  1. ↵*Corresponding author. Email: max.rousseaux{at}uottawa.ca
  1. ↵† Authors contributed equally

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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Jean-Louis A. Parmasad, Konrad M. Ricke, Morgan G. Stykel, Brodie Buchner-Duby, Eric Lian, Benjamin Nguyen, Nathalie A. Lengacher, Haley M. Geertsma, Amanda Bruce, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Patrik Brundin, Scott D. Ryan, Maxime W.C. Rousseaux
bioRxiv 2022.05.02.490309; doi: https://doi.org/10.1101/2022.05.02.490309
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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
Jean-Louis A. Parmasad, Konrad M. Ricke, Morgan G. Stykel, Brodie Buchner-Duby, Eric Lian, Benjamin Nguyen, Nathalie A. Lengacher, Haley M. Geertsma, Amanda Bruce, Steve M. Callaghan, Alvin Joselin, Julianna J. Tomlinson, Michael G. Schlossmacher, William L. Stanford, Patrik Brundin, Scott D. Ryan, Maxime W.C. Rousseaux
bioRxiv 2022.05.02.490309; doi: https://doi.org/10.1101/2022.05.02.490309

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