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Evaluation of Cognitive Function in the Dog Aging Project: Associations with Baseline Canine Characteristics

Sarah Yarborough, Annette Fitzpatrick, Stephen M. Schwartz, Dog Aging Project Consortium
doi: https://doi.org/10.1101/2022.05.04.490636
Sarah Yarborough
1Department of Epidemiology, University of Washington, Seattle WA
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  • For correspondence: sarahy24@uw.edu
Annette Fitzpatrick
1Department of Epidemiology, University of Washington, Seattle WA
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Stephen M. Schwartz
1Department of Epidemiology, University of Washington, Seattle WA
2Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, WA
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ABSTRACT

Canine Cognitive Dysfunction (CCD) is a neurodegenerative disease in aging dogs. It has been described previously in relatively small cohorts of dogs using multiple different rating scales. This study aimed to use a minimally modified CCD rating scale developed by previous researchers to describe the prevalence of CCD more thoroughly in a large, nationwide cohort of companion dogs participating in the Dog Aging Project (DAP). Associations between various canine characteristics, predicted lifespan quartiles, and CCD were examined using univariable and multivariable logistic regression models and Receiver Operating Curve (ROC) analysis.

When controlling for all other characteristics, the odds of CCD increased 52% with each additional year of age. Among dogs of the same age, health status, breed type, and sterilization status, odds of CCD were 6.47 times higher in dogs who were not active compared to those who were very active. When controlling for age, breed type, activity level, and other comorbidities, dogs with a history of neurological, eye, or ear disorders had higher odds of CCD. Lifespan quartile analysis showed excellent discriminating ability between CCD positive and negative dogs. Weight-based lifespan quartile estimation could therefore serve as a tool to inform CCD screening by veterinarians.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 05, 2022.
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Evaluation of Cognitive Function in the Dog Aging Project: Associations with Baseline Canine Characteristics
Sarah Yarborough, Annette Fitzpatrick, Stephen M. Schwartz, Dog Aging Project Consortium
bioRxiv 2022.05.04.490636; doi: https://doi.org/10.1101/2022.05.04.490636
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Evaluation of Cognitive Function in the Dog Aging Project: Associations with Baseline Canine Characteristics
Sarah Yarborough, Annette Fitzpatrick, Stephen M. Schwartz, Dog Aging Project Consortium
bioRxiv 2022.05.04.490636; doi: https://doi.org/10.1101/2022.05.04.490636

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