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Dynamic regulation of neural variability during working memory reflects dopamine, functional integration, and decision-making

View ORCID ProfileDouglas D. Garrett, View ORCID ProfileNiels A. Kloosterman, Samira Epp, Vivien Chopurian, View ORCID ProfileJulian Q. Kosciessa, View ORCID ProfileLeonhard Waschke, Alexander Skowron, View ORCID ProfileJames. M. Shine, Alistair Perry, Alireza Salami, Anna Rieckmann, Goran Papenberg, Anders Wåhlin, Nina Karalija, Micael Andersson, Katrine Riklund, Martin Lövdén, Lars Bäckman, Lars Nyberg, View ORCID ProfileUlman Lindenberger
doi: https://doi.org/10.1101/2022.05.05.490687
Douglas D. Garrett
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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  • For correspondence: garrett@mpib-berlin.mpg.de
Niels A. Kloosterman
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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Samira Epp
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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Vivien Chopurian
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
3Institute for Psychology, Humboldt Universität, Berlin
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Julian Q. Kosciessa
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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Leonhard Waschke
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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Alexander Skowron
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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James. M. Shine
4Brain and Mind Center, The University of Sydney, NSW, Australia
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Alistair Perry
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
5University of Cambridge, Cambridge, United Kingdom
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Alireza Salami
6Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
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Anna Rieckmann
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
9Max Planck Institute for Social Law and Social Policy, Munich, Germany
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Goran Papenberg
6Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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Anders Wåhlin
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
10Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden
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Nina Karalija
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Micael Andersson
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
11Department of Integrative Medical Biology, Umeå University, Umeå, Sweden
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Katrine Riklund
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
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Martin Lövdén
12Department of Psychology, University of Gothenberg, Sweden
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Lars Bäckman
6Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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Lars Nyberg
7Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden
8Department of Radiation Sciences, Umeå University, Umeå, Sweden
11Department of Integrative Medical Biology, Umeå University, Umeå, Sweden
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Ulman Lindenberger
1Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin/London
2Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
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  • ORCID record for Ulman Lindenberger
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Abstract

The regulation of moment-to-moment neural variability may permit effective responses to changing cognitive demands. However, the mechanisms that support variability regulation are unknown. In the context of working memory, we leverage the largest available PET and fMRI dataset to jointly consider three lenses through which neural variability regulation could be understood: dopamine capacity, network-level functional integration, and flexible decision processes. We show that with greater working memory load, upregulation of variability was associated with elevated dopamine capacity and heightened functional integration, effects dominantly expressed in the striato-thalamic system rather than cortex. Strikingly, behavioral modeling revealed that working memory load evoked substantial decision biases during evidence accumulation, and those who jointly expressed a more optimal decision bias and higher dopamine capacity were most likely to upregulate striato-thalamic variability under load. We argue that the ability to align striato-thalamic variability to level of demand may be a hallmark of a well-functioning brain.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 05, 2022.
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Dynamic regulation of neural variability during working memory reflects dopamine, functional integration, and decision-making
Douglas D. Garrett, Niels A. Kloosterman, Samira Epp, Vivien Chopurian, Julian Q. Kosciessa, Leonhard Waschke, Alexander Skowron, James. M. Shine, Alistair Perry, Alireza Salami, Anna Rieckmann, Goran Papenberg, Anders Wåhlin, Nina Karalija, Micael Andersson, Katrine Riklund, Martin Lövdén, Lars Bäckman, Lars Nyberg, Ulman Lindenberger
bioRxiv 2022.05.05.490687; doi: https://doi.org/10.1101/2022.05.05.490687
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Dynamic regulation of neural variability during working memory reflects dopamine, functional integration, and decision-making
Douglas D. Garrett, Niels A. Kloosterman, Samira Epp, Vivien Chopurian, Julian Q. Kosciessa, Leonhard Waschke, Alexander Skowron, James. M. Shine, Alistair Perry, Alireza Salami, Anna Rieckmann, Goran Papenberg, Anders Wåhlin, Nina Karalija, Micael Andersson, Katrine Riklund, Martin Lövdén, Lars Bäckman, Lars Nyberg, Ulman Lindenberger
bioRxiv 2022.05.05.490687; doi: https://doi.org/10.1101/2022.05.05.490687

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