Article Information
History
- May 6, 2022.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
Author Information
- Jonathan Bouvette1,#,
- Qinwen Huang2,#,
- Amanda A. Riccio1,
- William C. Copeland1,
- Alberto Bartesaghi2,3,4,* and
- Mario J. Borgnia1,*
- 1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, 27709, USA
- 2Department of Computer Science, Duke University, Durham, NC, 27708, USA
- 3Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27708, USA
- 4Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA
- ↵*Co-corresponding authors: Mario J. Borgnia and Alberto Bartesaghi, Email:
mario.borgnia2{at}nih.gov, alberto.bartesaghi{at}duke.edu
↵# These authors contributed equally
Author Contributions: J.B. and M.J.B. developed and implemented SmartScope, Q.H. and A.B. developed and implemented the AI detection and classification for SmartScope. A.A.R. and W.C.C. developed the POLG2 project, including the cloning and purification of the protein. A.A.R. prepared specimens, J.B. and A.R. screened the specimens and collected data. A.A.R. did the data analysis. J.B., Q.H., M.J.B and A.B. wrote the paper, J.B., Q.H. and A.A.R. prepared the figures, and J.B., M.J.B. and A.B. conceived the project.
Posted May 06, 2022.
