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A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin

Andrew D. Holmes, View ORCID ProfilePatricia P. Chan, View ORCID ProfileQi Chen, View ORCID ProfilePavel Ivanov, Laurence Drouard, View ORCID ProfileNorbert Polacek, View ORCID ProfileMark A. Kay, View ORCID ProfileTodd M. Lowe
doi: https://doi.org/10.1101/2022.05.06.490965
Andrew D. Holmes
1Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA
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Patricia P. Chan
1Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA
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Qi Chen
2Department of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, USA
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Pavel Ivanov
3Department of Medicine, Harvard Medical School, Boston, MA, USA
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Laurence Drouard
4Institut de biologie moléculaire des plantes-CNRS, Université de Strasbourg, 12 rue du Général Zimmer, 67084 Strasbourg, France
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Norbert Polacek
5Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
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Mark A. Kay
6Departments of Pediatrics and Genetics, Stanford University, Stanford, CA, USA
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Todd M. Lowe
1Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA
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  • For correspondence: tmjlowe@ucsc.edu
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Abstract

Small RNAs processed from transfer RNA are recognized to have regulatory functions distinct from protein synthesis. This rapidly advancing field has led to a constellation of transcript nomenclatures. Building upon the accepted tRNA naming system and linking tRNA-derived small RNAs to their molecular sources, we propose an improved nomenclature. Facilitated by the tDRnamer system, it will promote inter-study comparisons leveraging a biologically-rooted nomenclature for this emerging class of intriguing regulators.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • http://trna.ucsc.edu/tDRnamer/

  • http://trna.ucsc.edu/tDRnamer/data/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 08, 2022.
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A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin
Andrew D. Holmes, Patricia P. Chan, Qi Chen, Pavel Ivanov, Laurence Drouard, Norbert Polacek, Mark A. Kay, Todd M. Lowe
bioRxiv 2022.05.06.490965; doi: https://doi.org/10.1101/2022.05.06.490965
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A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin
Andrew D. Holmes, Patricia P. Chan, Qi Chen, Pavel Ivanov, Laurence Drouard, Norbert Polacek, Mark A. Kay, Todd M. Lowe
bioRxiv 2022.05.06.490965; doi: https://doi.org/10.1101/2022.05.06.490965

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