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Integrated Analysis of Tissue-specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases

View ORCID ProfileY-H. Taguchi, View ORCID ProfileTurki Turki
doi: https://doi.org/10.1101/2022.05.08.491060
Y-H. Taguchi
1Department of Physics, Chuo University, Tokyo 112-8551, Japan
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Turki Turki
2Department of Computer Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Abstract

In the field of gene expression analysis, methods of integrating multiple gene expression profiles are still being developed and the existing methods have scope for improvement. The previously proposed tensor decomposition-based unsupervised feature extraction method was improved by introducing standard deviation optimization. The improved method was applied to perform an integrated analysis of three tissue-specific gene expression profiles (namely, adipose, muscle, and liver) for diabetes mellitus, and the results showed that it can detect diseases that are associated with diabetes (e.g., neurodegenerative diseases) but that cannot be predicted by individual tissue expression analyses using state-of-the-art methods. Although the selected genes differed from those identified by the individual tissue analyses, the selected genes are known to be expressed in all three tissues. Thus, compared with individual tissue analyses, an integrated analysis can provide more in-depth data and identify additional factors, namely, the association with other diseases.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • tturki{at}kau.edu.sa

  • Revision based upon reviewers' comments

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 14, 2022.
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Integrated Analysis of Tissue-specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases
Y-H. Taguchi, Turki Turki
bioRxiv 2022.05.08.491060; doi: https://doi.org/10.1101/2022.05.08.491060
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Integrated Analysis of Tissue-specific Gene Expression in Diabetes by Tensor Decomposition Can Identify Possible Associated Diseases
Y-H. Taguchi, Turki Turki
bioRxiv 2022.05.08.491060; doi: https://doi.org/10.1101/2022.05.08.491060

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