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Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung
View ORCID ProfileTimothy Ting-Hsuan Wu, View ORCID ProfileKyle J. Travaglini, View ORCID ProfileArjun Rustagi, Duo Xu, Yue Zhang, SoRi K. Jang, Astrid Gillich, Roozbeh Dehghannasiri, Giovanny Martinez-Colon, Aimee Beck, Aaron J. Wilk, Maurizio Morri, Winston L. Trope, Joseph B. Shrager, View ORCID ProfileStephen R. Quake, Christin S. Kuo, Julia Salzman, Peter S. Kim, View ORCID ProfileCatherine A. Blish, View ORCID ProfileMark A. Krasnow
doi: https://doi.org/10.1101/2022.05.10.491266
Timothy Ting-Hsuan Wu
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
Kyle J. Travaglini
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
Arjun Rustagi
2Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA 94305
7Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA 94305
Duo Xu
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
13Stanford ChEM-H, Stanford University, Stanford, CA, USA 94305
Yue Zhang
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
11Department of Biology, Stanford University, Stanford, CA, USA 94305
SoRi K. Jang
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
Astrid Gillich
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
Roozbeh Dehghannasiri
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
6Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA 94305
Giovanny Martinez-Colon
2Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA 94305
7Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA 94305
Aimee Beck
2Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA 94305
Aaron J. Wilk
2Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA 94305
7Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA 94305
Maurizio Morri
10Chan Zuckerberg Biohub, San Francisco, CA, USA
Winston L. Trope
3Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA 94305
Joseph B. Shrager
3Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA 94305
8Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA
Stephen R. Quake
10Chan Zuckerberg Biohub, San Francisco, CA, USA
12Department of Bioengineering, Stanford University, Stanford, CA, USA 94305
Christin S. Kuo
5Department of Pediatrics, Pulmonary Medicine, Stanford University School of Medicine, Stanford, CA, USA 94305
Julia Salzman
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
6Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA 94305
Peter S. Kim
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
10Chan Zuckerberg Biohub, San Francisco, CA, USA
13Stanford ChEM-H, Stanford University, Stanford, CA, USA 94305
Catherine A. Blish
2Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA 94305
7Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA 94305
10Chan Zuckerberg Biohub, San Francisco, CA, USA
Mark A. Krasnow
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA 94305
4Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, CA, USA 94305
9Howard Hughes Medical Institute, San Francisco, CA, USA
Article usage
Posted May 10, 2022.
Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung
Timothy Ting-Hsuan Wu, Kyle J. Travaglini, Arjun Rustagi, Duo Xu, Yue Zhang, SoRi K. Jang, Astrid Gillich, Roozbeh Dehghannasiri, Giovanny Martinez-Colon, Aimee Beck, Aaron J. Wilk, Maurizio Morri, Winston L. Trope, Joseph B. Shrager, Stephen R. Quake, Christin S. Kuo, Julia Salzman, Peter S. Kim, Catherine A. Blish, Mark A. Krasnow
bioRxiv 2022.05.10.491266; doi: https://doi.org/10.1101/2022.05.10.491266
Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung
Timothy Ting-Hsuan Wu, Kyle J. Travaglini, Arjun Rustagi, Duo Xu, Yue Zhang, SoRi K. Jang, Astrid Gillich, Roozbeh Dehghannasiri, Giovanny Martinez-Colon, Aimee Beck, Aaron J. Wilk, Maurizio Morri, Winston L. Trope, Joseph B. Shrager, Stephen R. Quake, Christin S. Kuo, Julia Salzman, Peter S. Kim, Catherine A. Blish, Mark A. Krasnow
bioRxiv 2022.05.10.491266; doi: https://doi.org/10.1101/2022.05.10.491266
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