New Results
Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in TP53/CDKN2A-double knockout human gastroesophageal junction organoid model
Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen Khashab, Vikesh Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De-Chen Lin, Stephen J. Meltzer
doi: https://doi.org/10.1101/2022.05.10.491356
Hua Zhao
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
2Clinical Laboratory, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’ an, Shaanxi 710061, China
Yulan Cheng
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Andrew Kalra
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Ke Ma
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
3Einstein Healthcare Network, Philadelphia, PA 19136, USA
Yueyuan Zheng
4Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Benjamin Ziman
5Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Caitlin Tressler
6Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Kristine Glunde
6Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
7The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
8Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Eun Ji Shin
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Saowanee Ngamruengphong
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Mouen Khashab
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Vikesh Singh
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Robert A. Anders
9Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Simran Jit
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Nicolas Wyhs
7The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Wei Chen
2Clinical Laboratory, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’ an, Shaanxi 710061, China
Xu Li
10Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
De-Chen Lin
5Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA
Stephen J. Meltzer
1Division of Gastroenterology and Hepatology, Department of Medicine and Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine; Baltimore, MD 21287, USA
Posted May 11, 2022.
Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in TP53/CDKN2A-double knockout human gastroesophageal junction organoid model
Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen Khashab, Vikesh Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De-Chen Lin, Stephen J. Meltzer
bioRxiv 2022.05.10.491356; doi: https://doi.org/10.1101/2022.05.10.491356
Novel tumorigenic FOXM1-PTAFR-PTAF axis revealed by multi-omic profiling in TP53/CDKN2A-double knockout human gastroesophageal junction organoid model
Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen Khashab, Vikesh Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De-Chen Lin, Stephen J. Meltzer
bioRxiv 2022.05.10.491356; doi: https://doi.org/10.1101/2022.05.10.491356
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