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Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system

Donghoon Shin, Kayla Peelman, Joseph Del Rosario, View ORCID ProfileBilal Haider
doi: https://doi.org/10.1101/2022.05.19.491028
Donghoon Shin
1Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA
2Electrical and Computer Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA
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Kayla Peelman
1Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA
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Joseph Del Rosario
1Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA
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Bilal Haider
1Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, USA
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  • ORCID record for Bilal Haider
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Summary

Rhythmic oscillations of neural activity permeate sensory systems. Studies in the visual system propose that broadband gamma oscillations (30 – 80 Hz) facilitate neuronal communication underlying visual perception. However, broadband gamma oscillations within and across visual areas show widely varying frequency and phase, providing constraints for synchronizing spike timing. Here, we analyzed data from the Allen Brain Observatory and performed new experiments that show narrowband gamma (NBG) oscillations (50 – 70 Hz) propagate and synchronize throughout the awake mouse thalamocortical visual system. Lateral geniculate (LGN) neurons fired with millisecond precision relative to NBG phase in primary visual cortex (V1) and multiple higher visual areas (HVAs). NBG in HVAs depended upon retinotopically aligned V1 activity, and neurons that fired at NBG frequencies showed enhanced functional connectivity within and across visual areas. Remarkably, LGN ON versus OFF neurons showed distinct and reliable spike timing relative to NBG oscillation phase across LGN, V1, and HVAs. Taken together, NBG oscillations may serve as a novel substrate for precise coordination of spike timing in functionally distinct subnetworks of neurons spanning multiple brain areas during awake vision.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* Lead contact: bilal.haider{at}bme.gatech.edu

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 20, 2022.
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Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system
Donghoon Shin, Kayla Peelman, Joseph Del Rosario, Bilal Haider
bioRxiv 2022.05.19.491028; doi: https://doi.org/10.1101/2022.05.19.491028
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Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system
Donghoon Shin, Kayla Peelman, Joseph Del Rosario, Bilal Haider
bioRxiv 2022.05.19.491028; doi: https://doi.org/10.1101/2022.05.19.491028

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