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Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
doi: https://doi.org/10.1101/2022.05.20.492826
Laura K. Godfrey
1Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany
2Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany
Jan Forster
2Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany
3Genome Informatics, Institute of Human Genetics, University Duisburg-Essen, Essen, Germany
Sven-Thorsten Liffers
1Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany
2Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany
Christopher Schröder
3Genome Informatics, Institute of Human Genetics, University Duisburg-Essen, Essen, Germany
Johannes Köster
3Genome Informatics, Institute of Human Genetics, University Duisburg-Essen, Essen, Germany
4German Cancer Consortium (DKTK, partner site Essen), Essen, Germany
Leonie Henschel
5Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Kerstin U. Ludwig
5Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
Marija Trajkovic-Arsic
1Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany
2Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany
Diana Behrens
6EPO Experimental Pharmacology and Oncology GmbH, Berlin-Buch, Germany
Aldo Scarpa
7University and Hospital Trust of Verona, Department of Diagnostics and Public Health, Pathological Anatomy Section, Verona, Italy
8ARC-Net Cancer Research Centre, University and Hospital Trust of Verona, Verona, Italy
Rita T. Lawlor
8ARC-Net Cancer Research Centre, University and Hospital Trust of Verona, Verona, Italy
Kathrin E. Witzke
9Medizinisches Proteom-Center/Zentrum für Protein-Diagnostik, Ruhr-Universität Bochum, Bochum, Germany
Barbara Sitek
9Medizinisches Proteom-Center/Zentrum für Protein-Diagnostik, Ruhr-Universität Bochum, Bochum, Germany
Steven A. Johnsen
10Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany
11Robert Bosch Center for Tumor Diseases, Stuttgart, Germany
Sven Rahmann
3Genome Informatics, Institute of Human Genetics, University Duisburg-Essen, Essen, Germany
Bernhard Horsthemke
12Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen Germany
Michael Zeschnigk
4German Cancer Consortium (DKTK, partner site Essen), Essen, Germany
12Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen Germany
Jens T. Siveke
1Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany
2Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany
Posted May 20, 2022.
Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
bioRxiv 2022.05.20.492826; doi: https://doi.org/10.1101/2022.05.20.492826
Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
Laura K. Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schröder, Johannes Köster, Leonie Henschel, Kerstin U. Ludwig, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T. Lawlor, Kathrin E. Witzke, Barbara Sitek, Steven A. Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T. Siveke
bioRxiv 2022.05.20.492826; doi: https://doi.org/10.1101/2022.05.20.492826
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