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Accelerating single-cell genomic analysis with GPUs

Corey Nolet, View ORCID ProfileAvantika Lal, Rajesh Ilango, Taurean Dyer, Rajiv Movva, John Zedlewski, Johnny Israeli
doi: https://doi.org/10.1101/2022.05.26.493607
Corey Nolet
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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Avantika Lal
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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  • ORCID record for Avantika Lal
Rajesh Ilango
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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Taurean Dyer
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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Rajiv Movva
2Department of Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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John Zedlewski
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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Johnny Israeli
1NVIDIA Corporation, 2788 San Tomas Expy, Santa Clara, California 95051, USA
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  • For correspondence: jisraeli@nvidia.com
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Abstract

Single-cell genomic technologies are rapidly improving our understanding of cellular heterogeneity in biological systems. In recent years, technological and computational improvements have continuously increased the scale of single-cell experiments, and now allow for millions of cells to be analyzed in a single experiment. However, existing software tools for single-cell analysis do not scale well to such large datasets. RAPIDS is an open-source suite of Python libraries that use GPU computing to accelerate data science workflows. Here, we report the use of RAPIDS and GPU computing to accelerate single-cell genomic analysis workflows and present open-source examples that can be reused by the community.

Competing Interest Statement

C.N., R.I., T.D, J.Z., and J.I. are employees of NVIDIA Corporation.

Footnotes

  • https://github.com/clara-parabricks/rapids-single-cell-examples

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 28, 2022.
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Accelerating single-cell genomic analysis with GPUs
Corey Nolet, Avantika Lal, Rajesh Ilango, Taurean Dyer, Rajiv Movva, John Zedlewski, Johnny Israeli
bioRxiv 2022.05.26.493607; doi: https://doi.org/10.1101/2022.05.26.493607
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Accelerating single-cell genomic analysis with GPUs
Corey Nolet, Avantika Lal, Rajesh Ilango, Taurean Dyer, Rajiv Movva, John Zedlewski, Johnny Israeli
bioRxiv 2022.05.26.493607; doi: https://doi.org/10.1101/2022.05.26.493607

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