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Long-term Antibody Release Polycaprolactone (PCL) Capsule and the Release Kinetics In Natural and Accelerated Degradation

Waterkotte Thomas, Xingyu He, Apipa Wanasathop, Kevin Li, Yoonjee Park
doi: https://doi.org/10.1101/2022.06.06.493286
Waterkotte Thomas
University of Cincinnati
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Xingyu He
University of Cincinnati
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Apipa Wanasathop
University of Cincinnati
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Kevin Li
University of Cincinnati
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Yoonjee Park
University of Cincinnati
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  • For correspondence: parkye@ucmail.uc.edu
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Abstract

Although therapy using monoclonal antibodies (mAbs) has been steadily successful over the last 20 years, the means of delivery of mAbs has not been optimized, especially for long-term delivery. Frequent injections or infusions have been current standard of care. In this study, we have developed a long-term antibody biodegradable implant using a porous polycaprolactone (PCL) capsule. It released Bevacizumab (Bev) slowly for 8 months to date. The Bev release kinetics fit a drug release model with experimental data of the diffusion coefficient and partition coefficient through the polymer capsule. Since screening drug release profiles for the long-term (> 6 months) is time consuming, an accelerated degradation method was used after validating characteristics of the PCL capsule in natural and accelerated degradation conditions. The correlation of time period between the natural and the accelerated degradation was determined. Overall, the study suggests mAbs can be released from a porous PCL capsule without an effect of the polymer degradation over the long period (~ 6 months) and the long-term release kinetics can be determined by the accelerated degradation within 14 days.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 06, 2022.
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Long-term Antibody Release Polycaprolactone (PCL) Capsule and the Release Kinetics In Natural and Accelerated Degradation
Waterkotte Thomas, Xingyu He, Apipa Wanasathop, Kevin Li, Yoonjee Park
bioRxiv 2022.06.06.493286; doi: https://doi.org/10.1101/2022.06.06.493286
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Long-term Antibody Release Polycaprolactone (PCL) Capsule and the Release Kinetics In Natural and Accelerated Degradation
Waterkotte Thomas, Xingyu He, Apipa Wanasathop, Kevin Li, Yoonjee Park
bioRxiv 2022.06.06.493286; doi: https://doi.org/10.1101/2022.06.06.493286

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