Confirmatory Results
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
View ORCID ProfileMinee L. Choi, View ORCID ProfileAlexandre Chappard, View ORCID ProfileBhanu P. Singh, View ORCID ProfileCatherine Maclachlan, View ORCID ProfileMargarida Rodrigues, View ORCID ProfileEvgenia Fedotova, View ORCID ProfileAlexey V. Berezhnov, View ORCID ProfileSuman De, View ORCID ProfileChris Peddie, View ORCID ProfileDilan Athauda, View ORCID ProfileGurvir S. Virdi, View ORCID ProfileWeijia Zhang, View ORCID ProfileJames R. Evans, View ORCID ProfileAnna Wernick, View ORCID ProfileZeinab Shadman Zanjani, View ORCID ProfilePlamena R. Angelova, View ORCID ProfileNoemi Esteras, View ORCID ProfileAndrey Vinikurov, View ORCID ProfileKatie Morris, View ORCID ProfileKiani Jeacock, View ORCID ProfileLaura Tosatto, View ORCID ProfileDaniel Little, View ORCID ProfilePaul Gissen, View ORCID ProfileDavid J. Clarke, View ORCID ProfileTilo Kunath, View ORCID ProfileLucy Collinson, View ORCID ProfileDavid Klenerman, View ORCID ProfileAndrey Y. Abramov, View ORCID ProfileMathew H. Horrocks, View ORCID ProfileSonia Gandhi
doi: https://doi.org/10.1101/2022.06.07.494932
Minee L. Choi
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Alexandre Chappard
3EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK
Bhanu P. Singh
4School of Physics, The University of Edinburgh, Edinburgh EH9 3JZ, UK
Catherine Maclachlan
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Margarida Rodrigues
5Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
11Dementia Research institute at University of Cambridge, Cambridge, UK
Evgenia Fedotova
7Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia
8Cell Physiology and Pathology Laboratory, Orel State University, Orel, 302026, Russia
Alexey V. Berezhnov
7Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia
8Cell Physiology and Pathology Laboratory, Orel State University, Orel, 302026, Russia
Suman De
5Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
11Dementia Research institute at University of Cambridge, Cambridge, UK
Chris Peddie
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Dilan Athauda
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Gurvir S. Virdi
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Weijia Zhang
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
James R. Evans
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Anna Wernick
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Zeinab Shadman Zanjani
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Plamena R. Angelova
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
Noemi Esteras
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
Andrey Vinikurov
7Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia
13Cell Physiology & Pathology Laboratory at R&D Center of Biomedical Photonics, Orel, 302026, Russia
Katie Morris
3EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK
Kiani Jeacock
3EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK
Laura Tosatto
5Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
12Istituto di Biofisica, National Council of Research, via alla Cascata 56/C, 38123 Trento, Italy
Daniel Little
6MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
9NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK
Paul Gissen
6MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK
David J. Clarke
3EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK
Tilo Kunath
10Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh EH16 4UU, UK
Lucy Collinson
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
David Klenerman
5Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
11Dementia Research institute at University of Cambridge, Cambridge, UK
Andrey Y. Abramov
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
7Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290, Russia
Mathew H. Horrocks
3EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, UK
Sonia Gandhi
1Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK
2The Francis Crick Institute, Midland Rd, Kings Cross, London, NW1 1AT, UK
Posted June 09, 2022.
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgenia Fedotova, Alexey V. Berezhnov, Suman De, Chris Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Vinikurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
bioRxiv 2022.06.07.494932; doi: https://doi.org/10.1101/2022.06.07.494932
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgenia Fedotova, Alexey V. Berezhnov, Suman De, Chris Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Vinikurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
bioRxiv 2022.06.07.494932; doi: https://doi.org/10.1101/2022.06.07.494932
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