Abstract
Lp(a) is an important factor in Coronary Heart disease risk, and its expression is correlated with the length of the LPA gene. The KIV-2 region of LPA consists of variable tandem repeats whose number is highly variable across individuals. Little is known about the inner diversity of the KIV-2 repeats themselves. Here we utilize a pan-genome graph approach across 47 haplotype resolved assemblies to identify unexpected variation across KIV-2.
Competing Interest Statement
CC is an employee and stockholder of Sema4. FJS received research support from Illumina, Pacific Biosciences, and Oxford Nanopore.
Footnotes
The top and bottom of Figure 1 were cropped in the earlier version; docker link updated
Copyright
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