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A multi-level account of hippocampal function from behaviour to neurons

View ORCID ProfileRobert M. Mok, View ORCID ProfileBradley C. Love
doi: https://doi.org/10.1101/2022.06.09.495367
Robert M. Mok
1MRC Cognition and Brain Sciences Unit University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF
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  • For correspondence: rob.mok@mrc-cbu.cam.ac.uk b.love@ucl.ac.uk
Bradley C. Love
2UCL Department of Experimental Psychology 26 Bedford Way, London WC1H 0AP, United Kingdom
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Abstract

A complete neuroscience requires multi-level theories that address phenomena ranging from higher-level cognitive behaviors to activities within a cell. A levels-of-mechanism approach that decomposes a higher-level model of cognition and behavior into component mechanisms provides a coherent and richer understanding of the system than any level alone. Toward this end, we decomposed a cognitive model into neuron-like units using a neural flocking approach that parallels recurrent hippocampal activity. Neural flocking coordinates units that collectively form higher-level mental constructs. The decomposed model suggested how brain-scale neural populations coordinate to form assemblies encoding concept and spatial representations, and why so many neurons are needed for robust performance at the cognitive level. This multi-level explanation provides a way to understand how cognition and symbol-like representations are supported by coordinated neural populations (assemblies) formed through learning.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Reverting back to original preprint (as journal doesn't allow updating after peer review)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 17, 2023.
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A multi-level account of hippocampal function from behaviour to neurons
Robert M. Mok, Bradley C. Love
bioRxiv 2022.06.09.495367; doi: https://doi.org/10.1101/2022.06.09.495367
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A multi-level account of hippocampal function from behaviour to neurons
Robert M. Mok, Bradley C. Love
bioRxiv 2022.06.09.495367; doi: https://doi.org/10.1101/2022.06.09.495367

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