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Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2

Esther Wolf, Cristina Lento, Jinyue Pu, View ORCID ProfileBryan C. Dickinson, View ORCID ProfileDerek J. Wilson
doi: https://doi.org/10.1101/2022.06.10.495660
Esther Wolf
1Department of Chemistry, York University, Toronto, ON, Canada M3J 1P3
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Cristina Lento
1Department of Chemistry, York University, Toronto, ON, Canada M3J 1P3
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Jinyue Pu
2Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA
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Bryan C. Dickinson
2Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA
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Derek J. Wilson
1Department of Chemistry, York University, Toronto, ON, Canada M3J 1P3
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  • ORCID record for Derek J. Wilson
  • For correspondence: dkwilson@yorku.ca
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Article Information

doi 
https://doi.org/10.1101/2022.06.10.495660
History 
  • June 10, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Esther Wolf1,
  2. Cristina Lento1,
  3. Jinyue Pu2,
  4. Bryan C. Dickinson2 and
  5. Derek J. Wilson1,*
  1. 1Department of Chemistry, York University, Toronto, ON, Canada M3J 1P3
  2. 2Department of Chemistry, The University of Chicago, 5801 South Ellis Avenue, Chicago, IL, USA
  1. ↵*To whom correspondence should be addressed: Department of Chemistry, York University, Toronto, Canada M3J 1P3. Tel: 1-416-736-5936 x20786 Fax: 1-416-736-5936 e-mail: dkwilson{at}yorku.ca
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Posted June 10, 2022.
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Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2
Esther Wolf, Cristina Lento, Jinyue Pu, Bryan C. Dickinson, Derek J. Wilson
bioRxiv 2022.06.10.495660; doi: https://doi.org/10.1101/2022.06.10.495660
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Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2
Esther Wolf, Cristina Lento, Jinyue Pu, Bryan C. Dickinson, Derek J. Wilson
bioRxiv 2022.06.10.495660; doi: https://doi.org/10.1101/2022.06.10.495660

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