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A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
doi: https://doi.org/10.1101/2022.06.11.494613
Ana Vujovic
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Laura P.M.H. de Rooij
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Ava Keyvani Chahi
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
He Tian Chen
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Brian Yee
4Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
Sampath K Loganathan
5Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Lina Liu
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Derek C.H. Chan
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Amanda Tajik
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Emily Tsao
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Steven Moreira
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Pratik Joshi
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Joshua Xu
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
Nicholas Wong
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Sasan Zandi
6Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Stefan Aigner
4Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
John E. Dick
6Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Mark D. Minden
6Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
8Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Daniel Schramek
5Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Gene W. Yeo
4Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
Kristin J. Hope
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada
2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
Posted June 11, 2022.
A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
bioRxiv 2022.06.11.494613; doi: https://doi.org/10.1101/2022.06.11.494613
A two-step in vivo CRISPR screen unveils pervasive RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a therapeutic target
Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
bioRxiv 2022.06.11.494613; doi: https://doi.org/10.1101/2022.06.11.494613
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