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Running modulates primate and rodent visual cortex via common mechanism but quantitatively distinct implementation

John P. Liska, Declan P. Rowley, Trevor T. K. Nguyen, Jens-Oliver Muthmann, View ORCID ProfileDaniel A. Butts, View ORCID ProfileJacob L. Yates, View ORCID ProfileAlexander C. Huk
doi: https://doi.org/10.1101/2022.06.13.495712
John P. Liska
1Center for Perceptual Systems, Institute for Neuroscience, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin TX, 78712, USA
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Declan P. Rowley
1Center for Perceptual Systems, Institute for Neuroscience, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin TX, 78712, USA
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Trevor T. K. Nguyen
1Center for Perceptual Systems, Institute for Neuroscience, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin TX, 78712, USA
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Jens-Oliver Muthmann
1Center for Perceptual Systems, Institute for Neuroscience, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin TX, 78712, USA
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Daniel A. Butts
2Department of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park MD, 20742, USA
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  • ORCID record for Daniel A. Butts
Jacob L. Yates
2Department of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park MD, 20742, USA
3Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, CA, 94704, USA
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  • For correspondence: yates@berkeley.edu
Alexander C. Huk
1Center for Perceptual Systems, Institute for Neuroscience, Department of Neuroscience, Department of Psychology, The University of Texas at Austin, Austin TX, 78712, USA
4Fuster Laboratory, Departments of Psychiatry & Biobehavioral Sciences and Ophthalmology, UCLA, Los Angeles, CA, 90095, USA
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Abstract

When mice actively locomote, activity in their primary visual cortex (V1) is strongly modulated1. This observation has fundamentally altered conceptions of a brain region previously assumed to be a passive image processor, and extensive work has followed to dissect the sources, recipients, and functional consequences of running-correlated modulation2–13. However, it remains unclear whether visual processing in primates might similarly change during active locomotion. We therefore measured V1 activity in a nonhuman primate, the common marmoset (Callithrix jacchus), while they alternated between running and stationary. In contrast to the large increases in mouse V1 during running, responses in marmoset V1 were slightly but reliably decreased during running. Despite this superficially categorical difference, leveraging large-scale recordings to characterize the latent variables driving population activity revealed a common mechanism: trial-to-trial fluctuations of shared gain modulations were present across V1 in mice and marmosets. These gain modulations were larger in mice and were often positively correlated with running; they were smaller and more likely to be negatively correlated with running in marmosets. Thus, population-scale gain fluctuations reflect a common principle of mammalian visual cortical function, but important quantitative differences in their magnitudes and correlations with behavior produce distinct consequences for the relation between vision and action in primates versus rodents.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Formatting improved, readability improved, subsections added, minor numerical corrections

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 04, 2022.
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Running modulates primate and rodent visual cortex via common mechanism but quantitatively distinct implementation
John P. Liska, Declan P. Rowley, Trevor T. K. Nguyen, Jens-Oliver Muthmann, Daniel A. Butts, Jacob L. Yates, Alexander C. Huk
bioRxiv 2022.06.13.495712; doi: https://doi.org/10.1101/2022.06.13.495712
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Running modulates primate and rodent visual cortex via common mechanism but quantitatively distinct implementation
John P. Liska, Declan P. Rowley, Trevor T. K. Nguyen, Jens-Oliver Muthmann, Daniel A. Butts, Jacob L. Yates, Alexander C. Huk
bioRxiv 2022.06.13.495712; doi: https://doi.org/10.1101/2022.06.13.495712

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