New Results
Development of Top-Down Cortical Propagations in Youth
Adam Pines, Arielle S. Keller, Bart Larsen, Maxwell Bertolero, Arian Ashourvan, Dani S. Bassett, Matthew Cieslak, Sydney Covitz, Yong Fan, Eric Feczko, Audrey Houghton, Amanda R. Rueter, Tinashe Tapera, Jacob Vogel, Sarah M. Weinstein, Russell T. Shinohara, Damien Fair, Theodore Satterthwaite
doi: https://doi.org/10.1101/2022.06.14.496175
Adam Pines
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Arielle S. Keller
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Bart Larsen
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Maxwell Bertolero
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Arian Ashourvan
3Center for Neural Engineering, Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA
Dani S. Bassett
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
4Departments of Bioengineering, of the University of Pennsylvania, Philadelphia, PA 19104, USA
5Departments of Neurology, of the University of Pennsylvania, Philadelphia, PA 19104, USA
6Departments of Biostatistics, Epidemiology, and Informatics, of the University of Pennsylvania, Philadelphia, PA 19104, USA
7Departments of Electrical & Systems Engineering, of the University of Pennsylvania, Philadelphia, PA 19104, USA
8Departments of Physics & Astronomy of the University of Pennsylvania, Philadelphia, PA 19104, USA
9Santa Fe Institute, Santa Fe, NM 87051, USA
Matthew Cieslak
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Sydney Covitz
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Yong Fan
9Santa Fe Institute, Santa Fe, NM 87051, USA
Eric Feczko
10Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA
Audrey Houghton
10Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA
Amanda R. Rueter
10Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA
Tinashe Tapera
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Jacob Vogel
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Sarah M. Weinstein
6Departments of Biostatistics, Epidemiology, and Informatics, of the University of Pennsylvania, Philadelphia, PA 19104, USA
Russell T. Shinohara
6Departments of Biostatistics, Epidemiology, and Informatics, of the University of Pennsylvania, Philadelphia, PA 19104, USA
Damien Fair
10Masonic Institute for the Developing Brain, Institute of Child Development, College of Education and Human Development, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55414, USA
Theodore Satterthwaite
1The Penn Lifespan Informatics and Neuroimaging Center, of the University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Psychiatry, Neurodevelopment & Psychosis Section of the University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract
Hierarchical processing requires activity propagating between higher and lower-order cortical areas. However, studies of brain development have chiefly quantified fluctuations within regions over time rather than propagations occurring over space. Here, we leveraged advances in neuroimaging and computer vision to track cortical activity propagations in a large sample of youth (n=388). We found that propagations robustly ascend and descend the cortical hierarchy, and that top-down propagations become both more prevalent with cognitive control demands and with development in youth.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted June 15, 2022.
Development of Top-Down Cortical Propagations in Youth
Adam Pines, Arielle S. Keller, Bart Larsen, Maxwell Bertolero, Arian Ashourvan, Dani S. Bassett, Matthew Cieslak, Sydney Covitz, Yong Fan, Eric Feczko, Audrey Houghton, Amanda R. Rueter, Tinashe Tapera, Jacob Vogel, Sarah M. Weinstein, Russell T. Shinohara, Damien Fair, Theodore Satterthwaite
bioRxiv 2022.06.14.496175; doi: https://doi.org/10.1101/2022.06.14.496175
Development of Top-Down Cortical Propagations in Youth
Adam Pines, Arielle S. Keller, Bart Larsen, Maxwell Bertolero, Arian Ashourvan, Dani S. Bassett, Matthew Cieslak, Sydney Covitz, Yong Fan, Eric Feczko, Audrey Houghton, Amanda R. Rueter, Tinashe Tapera, Jacob Vogel, Sarah M. Weinstein, Russell T. Shinohara, Damien Fair, Theodore Satterthwaite
bioRxiv 2022.06.14.496175; doi: https://doi.org/10.1101/2022.06.14.496175
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