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Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus

Emilia McLaughlin, Annick Dujeancourt-Henry, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, View ORCID ProfileMichael D Urbaniak, Lucy Glover
doi: https://doi.org/10.1101/2022.06.15.496243
Emilia McLaughlin
1Institut Pasteur, Université Paris Cité, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, F-75015, Paris, France
2Sorbonne Université, Collège doctoral, F-75005 Paris, France
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Annick Dujeancourt-Henry
1Institut Pasteur, Université Paris Cité, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, F-75015, Paris, France
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Thibault Chaze
3Institut Pasteur, Université Paris Cité, Proteomics Platform, Mass Spectrometry for Biology Unit, Centre National de la Recherche Scientifique, UAR 2024, 75015 Paris, France
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Quentin Giai Gianetto
3Institut Pasteur, Université Paris Cité, Proteomics Platform, Mass Spectrometry for Biology Unit, Centre National de la Recherche Scientifique, UAR 2024, 75015 Paris, France
4Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics HUB, 75015 Paris, France
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Mariette Matondo
3Institut Pasteur, Université Paris Cité, Proteomics Platform, Mass Spectrometry for Biology Unit, Centre National de la Recherche Scientifique, UAR 2024, 75015 Paris, France
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Michael D Urbaniak
5Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK
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  • ORCID record for Michael D Urbaniak
Lucy Glover
1Institut Pasteur, Université Paris Cité, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, F-75015, Paris, France
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  • For correspondence: lucy.glover@pasteur.fr
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Article Information

doi 
https://doi.org/10.1101/2022.06.15.496243
History 
  • June 15, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Emilia McLaughlin1,2,#,
  2. Annick Dujeancourt-Henry1,
  3. Thibault Chaze3,
  4. Quentin Giai Gianetto3,4,
  5. Mariette Matondo3,
  6. Michael D Urbaniak5 and
  7. Lucy Glover1,*
  1. 1Institut Pasteur, Université Paris Cité, Trypanosome Molecular Biology, Department of Parasites and Insect Vectors, F-75015, Paris, France
  2. 2Sorbonne Université, Collège doctoral, F-75005 Paris, France
  3. 3Institut Pasteur, Université Paris Cité, Proteomics Platform, Mass Spectrometry for Biology Unit, Centre National de la Recherche Scientifique, UAR 2024, 75015 Paris, France
  4. 4Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics HUB, 75015 Paris, France
  5. 5Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK
  1. ↵*Corresponding author: Lucy Glover - lucy.glover{at}pasteur.fr
  • ↵# Present address

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Posted June 15, 2022.
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Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus
Emilia McLaughlin, Annick Dujeancourt-Henry, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Michael D Urbaniak, Lucy Glover
bioRxiv 2022.06.15.496243; doi: https://doi.org/10.1101/2022.06.15.496243
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Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus
Emilia McLaughlin, Annick Dujeancourt-Henry, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Michael D Urbaniak, Lucy Glover
bioRxiv 2022.06.15.496243; doi: https://doi.org/10.1101/2022.06.15.496243

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