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A G protein coupled receptor like protein systematically modulates nutrient-growth by Ca2+ mediated phosphatidylcholine perception during evolutionary adaptation

Zhixiong Huang, Xue He, Xueqiang Zhao, Wan Teng, Mengyun Hu, Yijing Zhang, Junming Li, Hui Li, Yiping Tong
doi: https://doi.org/10.1101/2022.06.17.496194
Zhixiong Huang
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
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Xue He
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
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Xueqiang Zhao
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
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Wan Teng
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
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Mengyun Hu
3Hebei Laboratory of Crop Genetics and Breeding, Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang, China
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Yijing Zhang
4State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200438, China
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Junming Li
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
5Center for Agricultural Resources Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Shijiazhuang 050022, China
6The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China
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Hui Li
3Hebei Laboratory of Crop Genetics and Breeding, Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang, China
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Yiping Tong
1State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
6The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China
7College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
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  • For correspondence: yptong@genetics.ac.cn
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Abstract

Nutrients are important for growth in both plants and animals, uncovering of signaling pathway in nutrients determined growth is essential. Here we cloned TaPCGR1-3B (Phospholipid Coordinated Growth and nutrients Response 1), controlled by SNPs on alternative splicing and transcription factors binding, conferring nitrogen deficiency response. TaPCGR1-3B was localized in plasma membrane and endoplasmic reticulum of meristem cell. Nitrogen deprivation stimulated interaction of TaPCGR1-3B with G protein alpha subunit and phospholipase C 9, which was inhibited by phosphatidylcholine, to trigger Ca2+ signaling and inhibit normal growth. Knockdown of TaPCGR1 rescued the growth inhibition caused by nutrient deficient conditions by modulation of phosphatidylcholine induced growth gene expression through Ca2+ signaling disruption. Modulating of phosphatidylcholine mediated TaPCGR1 activity thus tightly regulated growth through Ca2+ signaling.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 17, 2022.
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A G protein coupled receptor like protein systematically modulates nutrient-growth by Ca2+ mediated phosphatidylcholine perception during evolutionary adaptation
Zhixiong Huang, Xue He, Xueqiang Zhao, Wan Teng, Mengyun Hu, Yijing Zhang, Junming Li, Hui Li, Yiping Tong
bioRxiv 2022.06.17.496194; doi: https://doi.org/10.1101/2022.06.17.496194
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A G protein coupled receptor like protein systematically modulates nutrient-growth by Ca2+ mediated phosphatidylcholine perception during evolutionary adaptation
Zhixiong Huang, Xue He, Xueqiang Zhao, Wan Teng, Mengyun Hu, Yijing Zhang, Junming Li, Hui Li, Yiping Tong
bioRxiv 2022.06.17.496194; doi: https://doi.org/10.1101/2022.06.17.496194

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