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Epigenetic alterations in gut and brain of adult rats after oral administration of miR-320-3p and miR-375-3p at mid-lactation, and preventive potential of miR-320-3p on early weaning stress

Gabriel A Tavares, Amada Torres, Gwenola Le Drean, Maïwenn Queignec, Blandine Castellano, Laurent Tesson, Séverine Remy, Ignacio Annegone, Sandra L de Souza, Bruno Pitard, View ORCID ProfileBertrand Kaeffer
doi: https://doi.org/10.1101/2022.06.20.496755
Gabriel A Tavares
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
2Laboratory of Neuroplasticity and Behavior, Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil.
5Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, OH, USA
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Amada Torres
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
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Gwenola Le Drean
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
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Maïwenn Queignec
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
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Blandine Castellano
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
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Laurent Tesson
3Platform Rat Transgenesis Immunophenomic, INSERM UMR 1064-CRTI, SFR François Bonamy, CNRS UMS3556 Nantes, F44093, France
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Séverine Remy
3Platform Rat Transgenesis Immunophenomic, INSERM UMR 1064-CRTI, SFR François Bonamy, CNRS UMS3556 Nantes, F44093, France
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Ignacio Annegone
3Platform Rat Transgenesis Immunophenomic, INSERM UMR 1064-CRTI, SFR François Bonamy, CNRS UMS3556 Nantes, F44093, France
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Sandra L de Souza
2Laboratory of Neuroplasticity and Behavior, Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil.
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Bruno Pitard
4Nantes Université, Univ Angers, INSERM, CNRS, Immunology and New Concepts in Immunotherapy, INCIT UMR1302/EMR6001. F-44000 Nantes, France
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Bertrand Kaeffer
1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
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  • ORCID record for Bertrand Kaeffer
  • For correspondence: Kaeffer@univ-nantes.fr
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Article Information

doi 
https://doi.org/10.1101/2022.06.20.496755
History 
  • June 20, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Gabriel A Tavares1,2,5,*,
  2. Amada Torres1,*,
  3. Gwenola Le Drean1,
  4. Maïwenn Queignec1,
  5. Blandine Castellano1,
  6. Laurent Tesson3,
  7. Séverine Remy3,
  8. Ignacio Annegone3,
  9. Sandra L de Souza2,
  10. Bruno Pitard4 and
  11. Bertrand Kaeffer1,**
  1. 1Nantes Université, INRAE, UMR 1280, PhAN, F-44000 Nantes, France
  2. 2Laboratory of Neuroplasticity and Behavior, Graduate Program of Nutrition, Federal University of Pernambuco, Recife, Brazil.
  3. 3Platform Rat Transgenesis Immunophenomic, INSERM UMR 1064-CRTI, SFR François Bonamy, CNRS UMS3556 Nantes, F44093, France
  4. 4Nantes Université, Univ Angers, INSERM, CNRS, Immunology and New Concepts in Immunotherapy, INCIT UMR1302/EMR6001. F-44000 Nantes, France
  5. 5Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, OH, USA
  1. ↵** Corresponding author: Bertrand Kaeffer{at}univ-nantes.fr, see “Contribution of authors and correpondence section” for co-author emails.
  1. ↵* These authors contributed equally to the manuscript

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Epigenetic alterations in gut and brain of adult rats after oral administration of miR-320-3p and miR-375-3p at mid-lactation, and preventive potential of miR-320-3p on early weaning stress
Gabriel A Tavares, Amada Torres, Gwenola Le Drean, Maïwenn Queignec, Blandine Castellano, Laurent Tesson, Séverine Remy, Ignacio Annegone, Sandra L de Souza, Bruno Pitard, Bertrand Kaeffer
bioRxiv 2022.06.20.496755; doi: https://doi.org/10.1101/2022.06.20.496755
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Epigenetic alterations in gut and brain of adult rats after oral administration of miR-320-3p and miR-375-3p at mid-lactation, and preventive potential of miR-320-3p on early weaning stress
Gabriel A Tavares, Amada Torres, Gwenola Le Drean, Maïwenn Queignec, Blandine Castellano, Laurent Tesson, Séverine Remy, Ignacio Annegone, Sandra L de Souza, Bruno Pitard, Bertrand Kaeffer
bioRxiv 2022.06.20.496755; doi: https://doi.org/10.1101/2022.06.20.496755

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