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Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression

View ORCID ProfileJoseph Blayney, Helena Francis, Brendan Camellato, Leslie Mitchell, Rosa Stolper, View ORCID ProfileJef Boeke, View ORCID ProfileDouglas Higgs, Mira Kassouf
doi: https://doi.org/10.1101/2022.06.20.496856
Joseph Blayney
1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
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  • ORCID record for Joseph Blayney
Helena Francis
1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
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Brendan Camellato
2Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016
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Leslie Mitchell
2Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016
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Rosa Stolper
1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
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Jef Boeke
2Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016
3Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn NY 11201
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Douglas Higgs
1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
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  • ORCID record for Douglas Higgs
Mira Kassouf
1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
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  • For correspondence: mira.kassouf@imm.ox.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2022.06.20.496856
History 
  • June 22, 2022.

Article Versions

  • Version 1 (June 21, 2022 - 16:52).
  • You are currently viewing Version 2 of this article (June 22, 2022 - 21:31).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Joseph Blayney1,
  2. Helena Francis1,
  3. Brendan Camellato2,
  4. Leslie Mitchell2,
  5. Rosa Stolper1,
  6. Jef Boeke2,3,
  7. Douglas Higgs1 and
  8. Mira Kassouf1,*
  1. 1Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
  2. 2Institute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016
  3. 3Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn NY 11201
  1. ↵* Corresponding author; email: mira.kassouf{at}imm.ox.ac.uk
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Posted June 22, 2022.
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Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression
Joseph Blayney, Helena Francis, Brendan Camellato, Leslie Mitchell, Rosa Stolper, Jef Boeke, Douglas Higgs, Mira Kassouf
bioRxiv 2022.06.20.496856; doi: https://doi.org/10.1101/2022.06.20.496856
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Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression
Joseph Blayney, Helena Francis, Brendan Camellato, Leslie Mitchell, Rosa Stolper, Jef Boeke, Douglas Higgs, Mira Kassouf
bioRxiv 2022.06.20.496856; doi: https://doi.org/10.1101/2022.06.20.496856

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