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Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
View ORCID ProfileWenhao O. Ouyang, View ORCID ProfileTimothy J.C. Tan, View ORCID ProfileRuipeng Lei, View ORCID ProfileGe Song, View ORCID ProfileCollin Kieffer, View ORCID ProfileRaiees Andrabi, View ORCID ProfileKenneth A. Matreyek, View ORCID ProfileNicholas C. Wu
doi: https://doi.org/10.1101/2022.06.20.496903
Wenhao O. Ouyang
1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Timothy J.C. Tan
2Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Ruipeng Lei
1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Ge Song
3Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
4IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA
5Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA
Collin Kieffer
6Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Raiees Andrabi
3Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
4IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA
5Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA
Kenneth A. Matreyek
7Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Nicholas C. Wu
1Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
8Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
9Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Posted June 21, 2022.
Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
Wenhao O. Ouyang, Timothy J.C. Tan, Ruipeng Lei, Ge Song, Collin Kieffer, Raiees Andrabi, Kenneth A. Matreyek, Nicholas C. Wu
bioRxiv 2022.06.20.496903; doi: https://doi.org/10.1101/2022.06.20.496903
Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
Wenhao O. Ouyang, Timothy J.C. Tan, Ruipeng Lei, Ge Song, Collin Kieffer, Raiees Andrabi, Kenneth A. Matreyek, Nicholas C. Wu
bioRxiv 2022.06.20.496903; doi: https://doi.org/10.1101/2022.06.20.496903
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