New Results
A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
Kevin P. Guay, Roberta Ibba, JL Kiappes, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Snežana Vasiljević, Carlos P. Modenutti, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
doi: https://doi.org/10.1101/2022.06.21.496940
Kevin P. Guay
aDepartment of Biochemistry and Molecular Biology, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts, United States
Roberta Ibba
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
cDepartment of Medicine, Surgery and Pharmacy, University of Sassari, Via Muroni 23A, 07100, Sassari, Italy
JL Kiappes
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Maria De Benedictis
dInstitute of Sciences of Food Production, C.N.R. Unit of Lecce, via Monteroni, I-73100 Lecce, Italy
Ilaria Zeni
eDepartment of Cellular, Computational and Integrative Biology, University of Trento, 38123, Povo, TN, Italy
James D. Le Cornu
fWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Mario Hensen
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Anu V. Chandran
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Anastassia L. Kantsadi
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Alessandro T. Caputo
gBiomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, 343 Royal Parade, Parkville, Victoria, 3052, Australia
Juan I. Blanco Capurro
hDepartamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
iInstituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET. Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
Yusupha Bayo
jDepartment of Biosciences, University of Milano, via Celoria 26, I-20133 Milano, Italy
Johan C. Hill
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Kieran Hudson
kDepartment of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C. Canada V6T 1Z1
Andrea Lia
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
dInstitute of Sciences of Food Production, C.N.R. Unit of Lecce, via Monteroni, I-73100 Lecce, Italy
Snežana Vasiljević
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Carlos P. Modenutti
hDepartamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
iInstituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET. Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
Stephen G. Withers
kDepartment of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C. Canada V6T 1Z1
Marcelo Martí
hDepartamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
iInstituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN) CONICET. Ciudad Universitaria, Pab. II (CE1428EHA), Buenos Aires, Argentina
Emiliano Biasini
eDepartment of Cellular, Computational and Integrative Biology, University of Trento, 38123, Povo, TN, Italy
lDulbecco Telethon Institute, University of Trento, 38123, Povo, TN, Italy
Angelo Santino
dInstitute of Sciences of Food Production, C.N.R. Unit of Lecce, via Monteroni, I-73100 Lecce, Italy
Daniel N. Hebert
aDepartment of Biochemistry and Molecular Biology, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts, United States
Nicole Zitzmann
bOxford Glycobiology Institute, Biochemistry Department,University of Oxford, South Parks Road, Oxford OX1 3QU, England, United Kingdom
Pietro Roversi
jDepartment of Biosciences, University of Milano, via Celoria 26, I-20133 Milano, Italy
mInstitute of Agricultural Biology and Biotechnology, IBBA-CNR Unit of Milano, via Bassini 15, I-20133 Milano, Italy
nLeicester Institute of Chemical and Structural Biology and Department of Molecular and Cell Biology, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 7HR, England, United Kingdom
Posted June 21, 2022.
A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
Kevin P. Guay, Roberta Ibba, JL Kiappes, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Snežana Vasiljević, Carlos P. Modenutti, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
bioRxiv 2022.06.21.496940; doi: https://doi.org/10.1101/2022.06.21.496940
A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
Kevin P. Guay, Roberta Ibba, JL Kiappes, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Snežana Vasiljević, Carlos P. Modenutti, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
bioRxiv 2022.06.21.496940; doi: https://doi.org/10.1101/2022.06.21.496940
Subject Area
Subject Areas
- Biochemistry (11752)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14974)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28097)
- Molecular Biology (11594)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2886)
- Systems Biology (7340)
- Zoology (1651)