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Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy
Omar S. Sarkar, Howard Donninger, Numan Al Rayyan, Lewis C. Chew, Bryce Stamp, Xiang Zhang, Aaron Whitt, Chi Li, Melissa Hall, Robert A. Mitchell, Alfred Zippelius, John Eaton, Jason A. Chesney, Kavitha Yaddanapudi
doi: https://doi.org/10.1101/2022.06.22.497260
Omar S. Sarkar
1Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA
Howard Donninger
2Department of Medicine, University of Louisville, Louisville, KY, USA
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
4Molecular targets group, University of Louisville, Louisville, KY, USA
Numan Al Rayyan
2Department of Medicine, University of Louisville, Louisville, KY, USA
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Lewis C. Chew
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Bryce Stamp
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Xiang Zhang
5Department of Chemistry, University of Louisville, Louisville, KY, USA
Aaron Whitt
6Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA
Chi Li
2Department of Medicine, University of Louisville, Louisville, KY, USA
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
4Molecular targets group, University of Louisville, Louisville, KY, USA
6Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA
Melissa Hall
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Robert A. Mitchell
1Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA
7Department of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA
8Immuno-Oncology Group, Brown Cancer Center, University of Louisville, Louisville, KY, USA
Alfred Zippelius
9Center for Immunotherapy, Cancer Center Medical Oncology, University Hospital Basel, Switzerland
John Eaton
3James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
8Immuno-Oncology Group, Brown Cancer Center, University of Louisville, Louisville, KY, USA
Jason A. Chesney
2Department of Medicine, University of Louisville, Louisville, KY, USA
7Department of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA
8Immuno-Oncology Group, Brown Cancer Center, University of Louisville, Louisville, KY, USA
Kavitha Yaddanapudi
1Department of Microbiology & Immunology, University of Louisville, Louisville, KY, USA
7Department of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, USA
8Immuno-Oncology Group, Brown Cancer Center, University of Louisville, Louisville, KY, USA
Posted June 25, 2022.
Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy
Omar S. Sarkar, Howard Donninger, Numan Al Rayyan, Lewis C. Chew, Bryce Stamp, Xiang Zhang, Aaron Whitt, Chi Li, Melissa Hall, Robert A. Mitchell, Alfred Zippelius, John Eaton, Jason A. Chesney, Kavitha Yaddanapudi
bioRxiv 2022.06.22.497260; doi: https://doi.org/10.1101/2022.06.22.497260
Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy
Omar S. Sarkar, Howard Donninger, Numan Al Rayyan, Lewis C. Chew, Bryce Stamp, Xiang Zhang, Aaron Whitt, Chi Li, Melissa Hall, Robert A. Mitchell, Alfred Zippelius, John Eaton, Jason A. Chesney, Kavitha Yaddanapudi
bioRxiv 2022.06.22.497260; doi: https://doi.org/10.1101/2022.06.22.497260
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