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Backbone amides are key determinants of Cl− selectivity in CLC ion channels
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea, Jason Galpin, Christopher A. Ahern, View ORCID ProfileEmad Tajkhorshid, View ORCID ProfileAlessio Accardi
doi: https://doi.org/10.1101/2022.07.01.498497
Lilia Leisle
1Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA
Kin Lam
2Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, 14 Illinois 61801, USA
Sepehr Dehghani-Ghahnaviyeh
2Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, 14 Illinois 61801, USA
Eva Fortea
1Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA
3Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA
Jason Galpin
4Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
Christopher A. Ahern
4Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
Emad Tajkhorshid
2Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, 14 Illinois 61801, USA
Alessio Accardi
1Department of Anesthesiology, Weill Cornell Medical College, New York, NY, USA
3Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA
5Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA
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Posted July 03, 2022.
Backbone amides are key determinants of Cl− selectivity in CLC ion channels
Lilia Leisle, Kin Lam, Sepehr Dehghani-Ghahnaviyeh, Eva Fortea, Jason Galpin, Christopher A. Ahern, Emad Tajkhorshid, Alessio Accardi
bioRxiv 2022.07.01.498497; doi: https://doi.org/10.1101/2022.07.01.498497
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