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Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation
View ORCID ProfileEdmond R. Watson, View ORCID ProfileScott J. Novick, View ORCID ProfileMary E. Matyskiela, View ORCID ProfilePhilip P. Chamberlain, View ORCID ProfileAndres Hernandez de la Peña, View ORCID ProfileJin-Yi Zhu, Eileen Tran, View ORCID ProfilePatrick R. Griffin, View ORCID ProfileIngrid E. Wertz, View ORCID ProfileGabriel C. Lander
doi: https://doi.org/10.1101/2022.07.02.498551
Edmond R. Watson
1Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037
Scott J. Novick
2Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458
Mary E. Matyskiela
3Bristol-Myers Squibb, San Diego, CA 92121
Philip P. Chamberlain
3Bristol-Myers Squibb, San Diego, CA 92121
Andres Hernandez de la Peña
3Bristol-Myers Squibb, San Diego, CA 92121
Jin-Yi Zhu
3Bristol-Myers Squibb, San Diego, CA 92121
Eileen Tran
3Bristol-Myers Squibb, San Diego, CA 92121
Patrick R. Griffin
2Department of Molecular Medicine, Scripps Research, Jupiter, FL 33458
Ingrid E. Wertz
3Bristol-Myers Squibb, San Diego, CA 92121
Gabriel C. Lander
1Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037

Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted July 03, 2022.
Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation
Edmond R. Watson, Scott J. Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres Hernandez de la Peña, Jin-Yi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander
bioRxiv 2022.07.02.498551; doi: https://doi.org/10.1101/2022.07.02.498551
Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation
Edmond R. Watson, Scott J. Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres Hernandez de la Peña, Jin-Yi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander
bioRxiv 2022.07.02.498551; doi: https://doi.org/10.1101/2022.07.02.498551
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