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The emergence of new lineages of the Mpox virus could affect the 2022 outbreak

View ORCID ProfileMayla Abrahim, View ORCID ProfileAlexandro Guterres, View ORCID ProfilePatrícia Cristina da Costa Neves, Ana Paula Dinis Ano Bom
doi: https://doi.org/10.1101/2022.07.07.498743
Mayla Abrahim
1Laboratório de Tecnologia Imunológica, Instituto de Tecnologia em Imunobiológicos, Vice-Diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil
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Alexandro Guterres
1Laboratório de Tecnologia Imunológica, Instituto de Tecnologia em Imunobiológicos, Vice-Diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil
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  • For correspondence: guterres_rj@yahoo.com.br
Patrícia Cristina da Costa Neves
1Laboratório de Tecnologia Imunológica, Instituto de Tecnologia em Imunobiológicos, Vice-Diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil
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Ana Paula Dinis Ano Bom
1Laboratório de Tecnologia Imunológica, Instituto de Tecnologia em Imunobiológicos, Vice-Diretoria de Desenvolvimento Tecnológico, Bio-Manguinhos, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, RJ, Brazil
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Abstract

Human Mpox is a highly contagious viral disease caused by Mpox virus, currently causing outbreaks in various regions of the world and considered a global public health problem. Understanding how the virus adapts or transfers to a new host species is crucial for effective prevention and treatment of viral infections. A comprehensive analysis of 1,318 accessible Mpox genomes was conducted to assess potential phenotypic effects, incorporating the examination of pseudogenes, gene duplication and deletion, as well as sequences obtained from the 2022 outbreak. This study we analyzed the genomic sequences of Mpox viruses from different clades and found that only a small percentage of proteins were conserved across the analyzed clades, with many proteins exhibiting various mutations, indicating the potential correlation between lineage or clade and variations in the pathology of human Mpox disease. The study highlights the importance of analyzing aligned regions in viral genomes to understand the evolution of the virus and the impact of structural changes on protein functions. In brief, further investigations are required to establish a correlation between the effects of these genetic modifications and the novel transmission pathways, average age, clinical manifestations, and symptoms observed in the ongoing outbreak.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • We have extended analyzes from a protein cluster to the whole genome. Then we update the results and discussion.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 31, 2023.
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The emergence of new lineages of the Mpox virus could affect the 2022 outbreak
Mayla Abrahim, Alexandro Guterres, Patrícia Cristina da Costa Neves, Ana Paula Dinis Ano Bom
bioRxiv 2022.07.07.498743; doi: https://doi.org/10.1101/2022.07.07.498743
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The emergence of new lineages of the Mpox virus could affect the 2022 outbreak
Mayla Abrahim, Alexandro Guterres, Patrícia Cristina da Costa Neves, Ana Paula Dinis Ano Bom
bioRxiv 2022.07.07.498743; doi: https://doi.org/10.1101/2022.07.07.498743

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