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Generic Purpose Pharmacokinetics-Pharmacodynamics Mathematical Model For Nanomedicine Targeted Drug Delivery: Mouse Model

View ORCID ProfileTeddy Lazebnik, Hanna Weitman, Gal A. Kaminka
doi: https://doi.org/10.1101/2022.07.13.499855
Teddy Lazebnik
1Department of Computer Science, Bar Ilan University, Ramat Gan, Israel
2Department of Cancer Biology, Cancer Institute, University College London, London, UK
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  • ORCID record for Teddy Lazebnik
  • For correspondence: t.lazebnik@ucl.ac.uk
Hanna Weitman
1Department of Computer Science, Bar Ilan University, Ramat Gan, Israel
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Gal A. Kaminka
1Department of Computer Science, Bar Ilan University, Ramat Gan, Israel
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Abstract

Pharmaceutical nanoparticles (NPs) carrying molecular payloads are used for medical purposes such as diagnosis and medical treatment. Currently, the research process of discovering a new applicative candidate for efficient clinical treatment is a time- and resource-consuming process due to the uncertainty of how NP behaves which requires a large number of experiments to study the properties of NPs-based drugs for clinical usage. In silico experiments are known to be powerful tools for studying biological and clinical systems and evaluating a drug’s efficiency, which can significantly reduce the number of in vivo experiments required. To this extent, in this study, we present a novel spatio-temporal pharmacokinetics-pharmacodynamics (PKPD) model of NPs based drugs. The proposed model takes into consideration the blood flow in the cardiovascular system as well as PKPD dynamics taking place during the drug’s flow and in the target sites. We show that the proposed model has a better fidelity compared to previous models on five in vivo experiments with 13 different NPs, done on mice.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 14, 2022.
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Generic Purpose Pharmacokinetics-Pharmacodynamics Mathematical Model For Nanomedicine Targeted Drug Delivery: Mouse Model
Teddy Lazebnik, Hanna Weitman, Gal A. Kaminka
bioRxiv 2022.07.13.499855; doi: https://doi.org/10.1101/2022.07.13.499855
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Generic Purpose Pharmacokinetics-Pharmacodynamics Mathematical Model For Nanomedicine Targeted Drug Delivery: Mouse Model
Teddy Lazebnik, Hanna Weitman, Gal A. Kaminka
bioRxiv 2022.07.13.499855; doi: https://doi.org/10.1101/2022.07.13.499855

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