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Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

View ORCID ProfileColin Y. Kim, Andrew J. Mitchell, View ORCID ProfileDavid W. Kastner, Claire E. Albright, Michael Gutierrez, View ORCID ProfileChristopher M. Glinkerman, Heather J. Kulik, View ORCID ProfileJing-Ke Weng
doi: https://doi.org/10.1101/2022.07.19.500703
Colin Y. Kim
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
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  • ORCID record for Colin Y. Kim
Andrew J. Mitchell
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
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David W. Kastner
2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
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Claire E. Albright
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
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Michael Gutierrez
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
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Christopher M. Glinkerman
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
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  • ORCID record for Christopher M. Glinkerman
Heather J. Kulik
3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
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Jing-Ke Weng
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
4Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
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  • ORCID record for Jing-Ke Weng
  • For correspondence: wengj@wi.mit.edu
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Article Information

doi 
https://doi.org/10.1101/2022.07.19.500703
History 
  • December 1, 2022.

Article Versions

  • Version 1 (July 20, 2022 - 00:45).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Colin Y. Kim1,2,
  2. Andrew J. Mitchell1,
  3. David W. Kastner2,3,
  4. Claire E. Albright1,
  5. Michael Gutierrez1,
  6. Christopher M. Glinkerman1,
  7. Heather J. Kulik3 and
  8. Jing-Ke Weng1,4,*
  1. 1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, United States
  2. 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
  3. 3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
  4. 4Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States
  1. ↵*Email: wengj{at}wi.mit.edu
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Posted December 01, 2022.
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Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Colin Y. Kim, Andrew J. Mitchell, David W. Kastner, Claire E. Albright, Michael Gutierrez, Christopher M. Glinkerman, Heather J. Kulik, Jing-Ke Weng
bioRxiv 2022.07.19.500703; doi: https://doi.org/10.1101/2022.07.19.500703
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Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Colin Y. Kim, Andrew J. Mitchell, David W. Kastner, Claire E. Albright, Michael Gutierrez, Christopher M. Glinkerman, Heather J. Kulik, Jing-Ke Weng
bioRxiv 2022.07.19.500703; doi: https://doi.org/10.1101/2022.07.19.500703

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