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Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
View ORCID ProfileMichael S. Haney, View ORCID ProfileArchana Shankar, Ian Hsu, Masashi Miyauchi, View ORCID ProfileRóbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, View ORCID ProfileTony Wyss-Coray, Hiromitsu Nakauchi, View ORCID ProfileAdam C. Wilkinson
doi: https://doi.org/10.1101/2022.07.22.501030
Michael S. Haney
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
Archana Shankar
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
Ian Hsu
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
Masashi Miyauchi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Róbert Pálovics
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
Hwei Minn Khoo
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
Kyomi J. Igarashi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Joydeep Bhadury
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
6Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg; Gothenburg, Sweden
Christy Munson
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
Paul K. Mack
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Tze-Kai Tan
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
Tony Wyss-Coray
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine; Stanford, CA, USA
2Wu Tsai Neurosciences Institute, Stanford University; Stanford, CA, USA
7ChEM-H, Stanford University; Stanford, CA, USA
8Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine; Stanford, CA, USA
Hiromitsu Nakauchi
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
5Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA
9Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo; Tokyo, Japan
Adam C. Wilkinson
3MRC Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK
4Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine; Stanford, CA, USA
Article usage
Posted July 22, 2022.
Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
Michael S. Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C. Wilkinson
bioRxiv 2022.07.22.501030; doi: https://doi.org/10.1101/2022.07.22.501030
Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
Michael S. Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Róbert Pálovics, Hwei Minn Khoo, Kyomi J. Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam C. Wilkinson
bioRxiv 2022.07.22.501030; doi: https://doi.org/10.1101/2022.07.22.501030
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