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The 3D Structural Architecture of the Human Hand Area is Non-Topographic

View ORCID ProfileJuliane Doehler, View ORCID ProfileAlicia Northall, Peng Liu, View ORCID ProfileAlessio Fracasso, View ORCID ProfileAnastasia Chrysidou, Oliver Speck, View ORCID ProfileGabriele Lohmann, View ORCID ProfileThomas Wolbers, View ORCID ProfileEsther Kuehn
doi: https://doi.org/10.1101/2022.07.28.501903
Juliane Doehler
1Institute for Cognitive Neurology and Dementia Research (IKND), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
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  • For correspondence: juliane.doehler@med.ovgu.de
Alicia Northall
1Institute for Cognitive Neurology and Dementia Research (IKND), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
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Peng Liu
1Institute for Cognitive Neurology and Dementia Research (IKND), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
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Alessio Fracasso
3Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom
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Anastasia Chrysidou
1Institute for Cognitive Neurology and Dementia Research (IKND), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
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Oliver Speck
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
4Department of Biomedical Magnetic Resonance (BMMR), Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
6Leibniz Institute for Neurobiology, Magdeburg, Germany
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Gabriele Lohmann
7Max Planck Institute for Biological Cybernetics, Tübingen, Germany
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Thomas Wolbers
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
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Esther Kuehn
8Hertie Institute for Clinical Brain Research, Tübingen, Germany
1Institute for Cognitive Neurology and Dementia Research (IKND), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
2German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
5Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
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Abstract

The functional topography of the human primary somatosensory cortex (S1) hand area is a widely studied model system to understand sensory organization and plasticity. It is so far unclear whether or not the underlying 3D structural architecture also shows a topographic organization. We used 7T MRI data to quantify layer-specific myelin, iron and mineralization in relation to population receptive field maps of individual finger representations. This 3D description allowed us to identify a characteristic profile of layer-specific myelin and iron deposition in the S1 hand area, but revealed an absence of structural differences between individual finger representations, and an absence of low-myelin borders between individual fingers. Both, however, were detected between the hand and the face areas. Using markers of responsivity, precision and sensorimotor integration, we additionally phenotyped these microstructural features with respect to their relation to BOLD signal change and behavior. We conclude that the 3D structural architecture of the human hand area is non-topographic, other than in some monkey species, which suggests a high degree of flexibility for functional finger organization and plasticity in humans.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 01, 2022.
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The 3D Structural Architecture of the Human Hand Area is Non-Topographic
Juliane Doehler, Alicia Northall, Peng Liu, Alessio Fracasso, Anastasia Chrysidou, Oliver Speck, Gabriele Lohmann, Thomas Wolbers, Esther Kuehn
bioRxiv 2022.07.28.501903; doi: https://doi.org/10.1101/2022.07.28.501903
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The 3D Structural Architecture of the Human Hand Area is Non-Topographic
Juliane Doehler, Alicia Northall, Peng Liu, Alessio Fracasso, Anastasia Chrysidou, Oliver Speck, Gabriele Lohmann, Thomas Wolbers, Esther Kuehn
bioRxiv 2022.07.28.501903; doi: https://doi.org/10.1101/2022.07.28.501903

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