Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

Julie Chang; Aashrith Saraswathibhatla; Zhaoqiang Song; Sushama Varma; Colline Sanchez; Sucheta Srivastava; Katherine Liu; Michael C. Bassik; M. Peter Marinkovich; Louis Hodgson; Vivek Shenoy; Robert B. West; Ovijit Chaudhuri

doi:10.1101/2022.07.28.501930

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Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

Julie Chang, Aashrith Saraswathibhatla, Zhaoqiang Song, Sushama Varma, Colline Sanchez, Sucheta Srivastava, Katherine Liu, Michael C. Bassik, M. Peter Marinkovich, Louis Hodgson, Vivek Shenoy, Robert B. West, View ORCID ProfileOvijit Chaudhuri

doi: https://doi.org/10.1101/2022.07.28.501930

Julie Chang

1Department of Bioengineering, Stanford University, Stanford, CA, USA

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Aashrith Saraswathibhatla

2Department of Mechanical Engineering, Stanford University, Stanford, CA, USA

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Zhaoqiang Song

3Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA

4Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA

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Sushama Varma

5Department of Pathology, Stanford University Medical Center, Palo Alto, CA, USA

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Colline Sanchez

6Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

7Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, USA

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Sucheta Srivastava

5Department of Pathology, Stanford University Medical Center, Palo Alto, CA, USA

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Katherine Liu

8Department of Genetics, Stanford University Medical Center, Palo Alto, CA, USA

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Michael C. Bassik

8Department of Genetics, Stanford University Medical Center, Palo Alto, CA, USA

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M. Peter Marinkovich

9Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA

10Dermatology Service, VA Medical Center, Palo Alto, CA, USA

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Louis Hodgson

6Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA

7Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY, USA

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Vivek Shenoy

3Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA, USA

4Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA

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Robert B. West

5Department of Pathology, Stanford University Medical Center, Palo Alto, CA, USA

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Ovijit Chaudhuri

2Department of Mechanical Engineering, Stanford University, Stanford, CA, USA

11Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA

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ORCID record for Ovijit Chaudhuri
For correspondence: [email protected]

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Posted July 31, 2022.

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Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

bioRxiv 2022.07.28.501930; doi: https://doi.org/10.1101/2022.07.28.501930

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Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility

bioRxiv 2022.07.28.501930; doi: https://doi.org/10.1101/2022.07.28.501930

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