Abstract
Summary The outbreak of Monkeypox virus (MPXV) infection in May 2022 is declared a global health emergency by WHO. As of 28th July, 21067 cases have been confirmed and the numbers are on the rise. Unfortunately, MPXV pathophysiology and its underlying mechanisms are not yet understood. Likewise, the knowledge of biochemicals and drugs used against MPXV and their downstream effects is sparse. In this work, using Knowledge Graph (KG) representations we have depicted chemical and biological aspects of MPXV. To achieve this, we have collected and rationally assembled several biological study results, assays, drug candidates, and preclinical evidence to form a dynamic and comprehensive network. The KG is compliant with FAIR annotations allowing seamless transformation and integration to/with other formats and infrastructures.
Availability and implementation The Monkeypox knowledge graph is publicly available at https://github.com/Fraunhofer-ITMP/mpox-kg
Supplementary information Supplementary data are available at Bioinformatics online.
Contact Reagon.Karki{at}itmp.fraunhofer.de
Competing Interest Statement
The authors have declared no competing interest.
