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Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7 Tesla: Challenges and capabilities

View ORCID ProfileLonike K. Faes, View ORCID ProfileFederico De Martino, View ORCID ProfileLaurentius (Renzo) Huber
doi: https://doi.org/10.1101/2022.08.02.502460
Lonike K. Faes
1Department of Cognitive Neurosciences, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, The Netherlands
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  • For correspondence: l.faes@maastrichtuniversity.nl
Federico De Martino
1Department of Cognitive Neurosciences, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, The Netherlands
2Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN 55455
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Laurentius (Renzo) Huber
1Department of Cognitive Neurosciences, Faculty of Psychology and Neuroscience, Maastricht University, 6229 EV Maastricht, The Netherlands
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Abstract

The development of ultra high field (UHF) fMRI signal readout strategies and contrasts has led to the possibility of imaging the human brain in vivo and non-invasively at increasingly higher spatial resolutions of cortical layers and columns. One emergent layer-fMRI acquisition method with increasing popularity is the cerebral blood volume (CBV) sensitive sequence named vascular space occupancy (VASO). This approach has been shown to be mostly sensitive to locally-specific changes of laminar microvasculature, without unwanted biases of trans-laminar draining veins. Until now, however, VASO has not been applied in the technically challenging cortical area of the primary auditory cortex. Here, we developed a VASO imaging protocol for auditory neuroscientific applications. We describe the main challenges we encountered and the solutions we have adopted to mitigate them. With our optimized protocol, we investigate laminar responses to sounds. Finally, as proof of concept for future investigations, we map the topographic representation of frequency preference (tonotopy) in the auditory cortex.

Highlights

  • Layer fMRI VASO in the auditory cortex is challenging due to its physiology

  • After protocol optimization we show the applicability of VASO to the auditory cortex

  • Topographic maps obtained with VASO respect the large-scale tonotopic organization that has previously been shown with BOLD fMRI data.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵+ co-senior authors

  • https://doi.org/10.34894/WCUTUL

  • https://layerfmri.page.link/A1VASO_3DMAPS

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 03, 2022.
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Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7 Tesla: Challenges and capabilities
Lonike K. Faes, Federico De Martino, Laurentius (Renzo) Huber
bioRxiv 2022.08.02.502460; doi: https://doi.org/10.1101/2022.08.02.502460
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Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7 Tesla: Challenges and capabilities
Lonike K. Faes, Federico De Martino, Laurentius (Renzo) Huber
bioRxiv 2022.08.02.502460; doi: https://doi.org/10.1101/2022.08.02.502460

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