Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction

Akiko Ogawa; Seiya Ohira; Tatsuya Ikuta; Yuri Kato; Shota Yanagida; Yukina Ishii; Yasunari Kanda; Motohiro Nishida; Asuka Inoue; Fan-Yan Wei

doi:10.1101/2022.08.08.503256

New Results

Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction

Akiko Ogawa, Seiya Ohira, Tatsuya Ikuta, Yuri Kato, Shota Yanagida, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei

doi: https://doi.org/10.1101/2022.08.08.503256

Akiko Ogawa

1Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer (IDAC), Tohoku University; Sendai, Miyagi, 980-8575, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Seiya Ohira

1Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer (IDAC), Tohoku University; Sendai, Miyagi, 980-8575, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tatsuya Ikuta

2Laboratory of Molecular & Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yuri Kato

3Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shota Yanagida

4Division of Pharmacology, National Institute of Health Sciences, Kanagawa 210-9501, Japan.

5Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yukina Ishii

3Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yasunari Kanda

4Division of Pharmacology, National Institute of Health Sciences, Kanagawa 210-9501, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Motohiro Nishida

3Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

6National Institute for Physiological Sciences and Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Asuka Inoue

2Laboratory of Molecular & Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.