Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

Yuanzi Sun; Kezia Jack; Tiziana Ercolani; Daljit Sangar; Laszlo Hosszu; John Collinge; Jan Bieschke

doi:10.1101/2022.08.10.503301

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Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

Yuanzi Sun, Kezia Jack, Tiziana Ercolani, Daljit Sangar, Laszlo Hosszu, John Collinge, Jan Bieschke

doi: https://doi.org/10.1101/2022.08.10.503301

Yuanzi Sun

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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Kezia Jack

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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Tiziana Ercolani

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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Daljit Sangar

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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Laszlo Hosszu

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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John Collinge

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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Jan Bieschke

1MRC Prion Unit at UCL / UCL Institute of Prion Diseases, Courtauld Building, London W1W 7FF, UK

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For correspondence: [email protected]

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Posted August 13, 2022.

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Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

Yuanzi Sun, Kezia Jack, Tiziana Ercolani, Daljit Sangar, Laszlo Hosszu, John Collinge, Jan Bieschke

bioRxiv 2022.08.10.503301; doi: https://doi.org/10.1101/2022.08.10.503301

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Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics

Yuanzi Sun, Kezia Jack, Tiziana Ercolani, Daljit Sangar, Laszlo Hosszu, John Collinge, Jan Bieschke

bioRxiv 2022.08.10.503301; doi: https://doi.org/10.1101/2022.08.10.503301

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