A framework evaluating the utility of multi-gene, multi-disease population-based panel testing that accounts for uncertainty in penetrance estimates

Jane W. Liang; Kurt D. Christensen; Robert C. Green; Peter Kraft

doi:10.1101/2022.08.10.503415

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A framework evaluating the utility of multi-gene, multi-disease population-based panel testing that accounts for uncertainty in penetrance estimates

View ORCID ProfileJane W. Liang, Kurt D. Christensen, Robert C. Green, View ORCID ProfilePeter Kraft

doi: https://doi.org/10.1101/2022.08.10.503415

Jane W. Liang

1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

2Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA

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ORCID record for Jane W. Liang
For correspondence: jwliang@g.harvard.edu

Kurt D. Christensen

3Center for Healthcare Research in Pediatrics, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, Massachusetts

4Department of Population Medicine, Harvard Medical School, Boston, Massachusetts

5Broad Institute of MIT and Harvard, Cambridge, Massachusetts

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Robert C. Green

6Mass General Brigham, Boston, MA, USA

5Broad Institute of MIT and Harvard, Cambridge, Massachusetts

7Ariadne Labs, Boston, MA, USA

8Harvard Medical School, Boston, MA, USA

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Peter Kraft

9Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

10Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

5Broad Institute of MIT and Harvard, Cambridge, Massachusetts

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ORCID record for Peter Kraft

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Posted August 13, 2022.

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A framework evaluating the utility of multi-gene, multi-disease population-based panel testing that accounts for uncertainty in penetrance estimates

Jane W. Liang, Kurt D. Christensen, Robert C. Green, Peter Kraft

bioRxiv 2022.08.10.503415; doi: https://doi.org/10.1101/2022.08.10.503415

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A framework evaluating the utility of multi-gene, multi-disease population-based panel testing that accounts for uncertainty in penetrance estimates

Jane W. Liang, Kurt D. Christensen, Robert C. Green, Peter Kraft

bioRxiv 2022.08.10.503415; doi: https://doi.org/10.1101/2022.08.10.503415

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