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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Peggy P. Hsu, View ORCID ProfileBrian T. Do, Sidney Y. Vermeulen, Zhishan Wang, Taghreed Hirz, Najihah Aziz, Joseph M. Replogle, Keene L. Abbott, Samuel Block, Alicia M. Darnell, Raphael Ferreira, Jelena Milosevic, Daniel R. Schmidt, Christopher Chidley, Xiaofeng A. Su, Isaac S. Harris, Jonathan S. Weissman, View ORCID ProfileSihem Cheloufi, David B. Sykes, View ORCID ProfileMatthew G. Vander Heiden
doi: https://doi.org/10.1101/2022.08.16.503984
Peggy P. Hsu
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2Dana-Farber Cancer Institute, Boston, MA 02115, USA
3Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Brian T. Do
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
4Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Sidney Y. Vermeulen
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
6Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Zhishan Wang
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Taghreed Hirz
3Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA
Najihah Aziz
3Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA
Joseph M. Replogle
7Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
8Medical Scientist Training Program, University of California, San Francisco, CA 94158, USA
Keene L. Abbott
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Samuel Block
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Alicia M. Darnell
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Raphael Ferreira
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
9Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Jelena Milosevic
3Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA
Daniel R. Schmidt
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
10Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Christopher Chidley
11Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Xiaofeng A. Su
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Isaac S. Harris
12Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
Jonathan S. Weissman
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
7Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA
13Howard Hughes Medical Institute, Cambridge, MA 02139, USA
Sihem Cheloufi
14Department of Biochemistry, University of California, Riverside, CA 92521, USA
15Stem Cell Center, University of California, Riverside, CA 92521, USA
David B. Sykes
3Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA
16Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02113, USA
17Harvard Stem Cell Institute, Cambridge, MA 02139, USA
Matthew G. Vander Heiden
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
2Dana-Farber Cancer Institute, Boston, MA 02115, USA
5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Article usage
Posted August 16, 2022.
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Peggy P. Hsu, Brian T. Do, Sidney Y. Vermeulen, Zhishan Wang, Taghreed Hirz, Najihah Aziz, Joseph M. Replogle, Keene L. Abbott, Samuel Block, Alicia M. Darnell, Raphael Ferreira, Jelena Milosevic, Daniel R. Schmidt, Christopher Chidley, Xiaofeng A. Su, Isaac S. Harris, Jonathan S. Weissman, Sihem Cheloufi, David B. Sykes, Matthew G. Vander Heiden
bioRxiv 2022.08.16.503984; doi: https://doi.org/10.1101/2022.08.16.503984
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Peggy P. Hsu, Brian T. Do, Sidney Y. Vermeulen, Zhishan Wang, Taghreed Hirz, Najihah Aziz, Joseph M. Replogle, Keene L. Abbott, Samuel Block, Alicia M. Darnell, Raphael Ferreira, Jelena Milosevic, Daniel R. Schmidt, Christopher Chidley, Xiaofeng A. Su, Isaac S. Harris, Jonathan S. Weissman, Sihem Cheloufi, David B. Sykes, Matthew G. Vander Heiden
bioRxiv 2022.08.16.503984; doi: https://doi.org/10.1101/2022.08.16.503984
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