Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

Chun-Hao Pan; Nina V. Chaika; Robert Tseng; Md Afjalus Siraj; Bo Chen; Katie L. Donnelly; Michael Horowitz; Cindy V. Leiton; Sumedha Chowdhury; Lucia Roa-Peña; Lyanne Oblein; Natalia Marchenko; Pankaj K. Singh; Kenneth R. Shroyer; Luisa F. Escobar-Hoyos

doi:10.1101/2022.08.24.504873

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Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

View ORCID ProfileChun-Hao Pan, Nina V. Chaika, Robert Tseng, Md Afjalus Siraj, Bo Chen, Katie L. Donnelly, Michael Horowitz, Cindy V. Leiton, Sumedha Chowdhury, Lucia Roa-Peña, Lyanne Oblein, Natalia Marchenko, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

doi: https://doi.org/10.1101/2022.08.24.504873

Chun-Hao Pan

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

2Molecular and Cellular Biology Graduate Program, Stony Brook University, Stony Brook, NY, US

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Nina V. Chaika

3Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, US

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Robert Tseng

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Md Afjalus Siraj

4Department of Therapeutic Radiology and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, US

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Bo Chen

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Katie L. Donnelly

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Michael Horowitz

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Cindy V. Leiton

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Sumedha Chowdhury

4Department of Therapeutic Radiology and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, US

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Lucia Roa-Peña

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Lyanne Oblein

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Natalia Marchenko

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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Pankaj K. Singh

3Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, US

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For correspondence: pankaj-singh@ouhsc.edu Kenneth.Shroyer@stonybrookmedicine.edu luisa.escobar-hoyos@yale.edu

Kenneth R. Shroyer

1Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, US

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For correspondence: pankaj-singh@ouhsc.edu Kenneth.Shroyer@stonybrookmedicine.edu luisa.escobar-hoyos@yale.edu

Luisa F. Escobar-Hoyos

4Department of Therapeutic Radiology and Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, US

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For correspondence: pankaj-singh@ouhsc.edu Kenneth.Shroyer@stonybrookmedicine.edu luisa.escobar-hoyos@yale.edu

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Posted August 26, 2022.

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Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

Chun-Hao Pan, Nina V. Chaika, Robert Tseng, Md Afjalus Siraj, Bo Chen, Katie L. Donnelly, Michael Horowitz, Cindy V. Leiton, Sumedha Chowdhury, Lucia Roa-Peña, Lyanne Oblein, Natalia Marchenko, Pankaj K. Singh, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos

bioRxiv 2022.08.24.504873; doi: https://doi.org/10.1101/2022.08.24.504873

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