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Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain

Leerang Yang, Matthew Van Beek, Zijun Wang, Frauke Muecksch, Marie Canis, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig, Arup K. Chakraborty
doi: https://doi.org/10.1101/2022.08.24.505127
Leerang Yang
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
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Matthew Van Beek
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
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Zijun Wang
2Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
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Frauke Muecksch
3Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA
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Marie Canis
3Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA
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Theodora Hatziioannou
3Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA
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Paul D. Bieniasz
3Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA
4Howard Hughes Medical Institute.
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Michel C. Nussenzweig
2Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
4Howard Hughes Medical Institute.
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  • For correspondence: arupc@mit.edu nussen@mail.rockefeller.edu
Arup K. Chakraborty
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
5Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.
6Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
7Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139.
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  • For correspondence: arupc@mit.edu nussen@mail.rockefeller.edu
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Article Information

doi 
https://doi.org/10.1101/2022.08.24.505127
History 
  • August 25, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Leerang Yang1,
  2. Matthew Van Beek1,
  3. Zijun Wang2,
  4. Frauke Muecksch3,
  5. Marie Canis3,
  6. Theodora Hatziioannou3,
  7. Paul D. Bieniasz3,4,
  8. Michel C. Nussenzweig2,4,* and
  9. Arup K. Chakraborty1,5,6,7,*
  1. 1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139
  2. 2Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
  3. 3Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA
  4. 4Howard Hughes Medical Institute.
  5. 5Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139.
  6. 6Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
  7. 7Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02139.
  1. ↵*Correspondence to: arupc{at}mit.edu or nussen{at}mail.rockefeller.edu
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Posted August 25, 2022.
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Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain
Leerang Yang, Matthew Van Beek, Zijun Wang, Frauke Muecksch, Marie Canis, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig, Arup K. Chakraborty
bioRxiv 2022.08.24.505127; doi: https://doi.org/10.1101/2022.08.24.505127
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Antigen presentation dynamics shape the response to emergent variants like SARS-CoV-2 Omicron strain after multiple vaccinations with wild type strain
Leerang Yang, Matthew Van Beek, Zijun Wang, Frauke Muecksch, Marie Canis, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig, Arup K. Chakraborty
bioRxiv 2022.08.24.505127; doi: https://doi.org/10.1101/2022.08.24.505127

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