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Auditory accessory stimulus boosts pupil-linked arousal and reduces choice bias

B.M. Bruel, V.G. Katopodis, R. de Vries, View ORCID ProfileT.H. Donner, View ORCID ProfileM.J. McGinley, View ORCID ProfileJ.W. de Gee
doi: https://doi.org/10.1101/2022.08.28.505585
B.M. Bruel
1Brain and Cognition, Department of Psychology, University of Amsterdam, Amsterdam, NLD
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V.G. Katopodis
1Brain and Cognition, Department of Psychology, University of Amsterdam, Amsterdam, NLD
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R. de Vries
1Brain and Cognition, Department of Psychology, University of Amsterdam, Amsterdam, NLD
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T.H. Donner
2Bernstein Center for Computational Neuroscience, Charité Universitätsmedizin, Berlin, DEU
3Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, DEU
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M.J. McGinley
4Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
5Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA
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J.W. de Gee
1Brain and Cognition, Department of Psychology, University of Amsterdam, Amsterdam, NLD
4Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
5Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX, USA
7Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, NLD
8Amsterdam Brain & Cognition, University of Amsterdam, Amsterdam, The Netherlands
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  • For correspondence: j.w.degee@uva.nl
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Abstract

Recent work indicates that pupil-linked phasic arousal signals reduce the impact of prior expectations and biases on decision formation. It has remained unclear whether phasic arousal (i) causes the bias reduction, if (ii) choosing against one’s bias causes phasic arousal, or if (iii) a third variable is driving both. Here, using an auditory accessory stimulus, we found evidence for the first scenario: on accessory stimulus vs normal trials, pupil-linked phasic arousal was robustly elevated and choice bias was reduced. With computational modeling of behavior, we established that the bias reduction was not due to a change in response caution (i.e., speed-accuracy tradeoff), but due to a change in a bias in the accumulation of evidence leading up to a choice. Thus, pupil-linked phasic arousal shapes choice behavior.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 29, 2022.
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Auditory accessory stimulus boosts pupil-linked arousal and reduces choice bias
B.M. Bruel, V.G. Katopodis, R. de Vries, T.H. Donner, M.J. McGinley, J.W. de Gee
bioRxiv 2022.08.28.505585; doi: https://doi.org/10.1101/2022.08.28.505585
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Auditory accessory stimulus boosts pupil-linked arousal and reduces choice bias
B.M. Bruel, V.G. Katopodis, R. de Vries, T.H. Donner, M.J. McGinley, J.W. de Gee
bioRxiv 2022.08.28.505585; doi: https://doi.org/10.1101/2022.08.28.505585

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