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Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity

View ORCID ProfileBenjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. Shao, Dipika Singh, Kellie N. Smith, Valsamo Anagnostou, View ORCID ProfileRachel Karchin
doi: https://doi.org/10.1101/2022.08.29.505690
Benjamin Alexander Albert
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
2Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA
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  • ORCID record for Benjamin Alexander Albert
Yunxiao Yang
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
2Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA
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Xiaoshan M. Shao
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
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Dipika Singh
3The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
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Kellie N. Smith
3The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
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Valsamo Anagnostou
3The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
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Rachel Karchin
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
2Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA
3The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
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  • ORCID record for Rachel Karchin
  • For correspondence: karchin@jhu.edu
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  • https://github.com/KarchinLab/bigmhc

  • https://doi.org/10.17632/dvmz6pkzvb.1

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Posted January 18, 2023.
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Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity
Benjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. Shao, Dipika Singh, Kellie N. Smith, Valsamo Anagnostou, Rachel Karchin
bioRxiv 2022.08.29.505690; doi: https://doi.org/10.1101/2022.08.29.505690
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Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity
Benjamin Alexander Albert, Yunxiao Yang, Xiaoshan M. Shao, Dipika Singh, Kellie N. Smith, Valsamo Anagnostou, Rachel Karchin
bioRxiv 2022.08.29.505690; doi: https://doi.org/10.1101/2022.08.29.505690

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