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Contrast and luminance gain control in the macaque’s lateral geniculate nucleus

View ORCID ProfileR.T. Raghavan, View ORCID ProfileJenna G. Kelly, View ORCID ProfileJ. Michael Hasse, View ORCID ProfilePaul G. Levy, View ORCID ProfileMichael J. Hawken, View ORCID ProfileJ. Anthony Movshon
doi: https://doi.org/10.1101/2022.08.29.505733
R.T. Raghavan
aCenter for Neural Science, New York University, New York, New York, 10003
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Jenna G. Kelly
aCenter for Neural Science, New York University, New York, New York, 10003
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J. Michael Hasse
aCenter for Neural Science, New York University, New York, New York, 10003
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Paul G. Levy
aCenter for Neural Science, New York University, New York, New York, 10003
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Michael J. Hawken
aCenter for Neural Science, New York University, New York, New York, 10003
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J. Anthony Movshon
aCenter for Neural Science, New York University, New York, New York, 10003
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  • For correspondence: movshon@nyu.edu
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Abstract

In natural scenes, there is substantial variation in the mean and fluctuation of light levels (luminance and contrast). Retinal ganglion cells maintain their sensitivity despite this variation and their limited signaling bandwidth using two adaptive mechanisms, which control luminance and contrast gain. However, the signature of each mechanism and their interactions further downstream of the retina are unknown. We recorded neurons in the magnocellular and parvocellular layers of the lateral geniculate nucleus (LGN) in anesthetized adult male macaques and characterized how they adapt to changes in contrast and luminance. As contrast increases, neurons in the magnocellular layers maintain sensitivity to high temporal frequency stimuli but attenuate sensitivity to low temporal-frequency stimuli. Neurons in the parvocellular layers do not adapt to changes in contrast. As luminance increases, magnocellular and parvocellular cells increase their sensitivity to high temporal frequency stimuli. Adaptation to luminance is independent of adaptation to contrast, as previously reported for LGN neurons in the cat. Our results are similar to those previously reported for macaque retinal ganglion cells, suggesting that adaptation to luminance and contrast result from two independent mechanisms that are retinal in origin.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The legend in a subplot in Figure 5; Author initials and ORCIDs; A line in results referencing figure 4 su panels;

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 31, 2022.
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Contrast and luminance gain control in the macaque’s lateral geniculate nucleus
R.T. Raghavan, Jenna G. Kelly, J. Michael Hasse, Paul G. Levy, Michael J. Hawken, J. Anthony Movshon
bioRxiv 2022.08.29.505733; doi: https://doi.org/10.1101/2022.08.29.505733
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Contrast and luminance gain control in the macaque’s lateral geniculate nucleus
R.T. Raghavan, Jenna G. Kelly, J. Michael Hasse, Paul G. Levy, Michael J. Hawken, J. Anthony Movshon
bioRxiv 2022.08.29.505733; doi: https://doi.org/10.1101/2022.08.29.505733

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