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Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes

View ORCID ProfileSathishkumar Chandrakumar, Irene Santiago Tierno, View ORCID ProfileMahesh Agarwal, View ORCID ProfileNikolaos Matisioudis, View ORCID ProfileTimothy S. Kern, View ORCID ProfileKaustabh Ghosh
doi: https://doi.org/10.1101/2022.08.31.505952
Sathishkumar Chandrakumar
1Department of Bioengineering, University of California, Riverside, CA, USA 92521
2Department of Ophthalmology, University of California, Los Angeles, CA, USA 90095
3Doheny Eye Institute, Pasadena, CA, USA 91103
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  • ORCID record for Sathishkumar Chandrakumar
Irene Santiago Tierno
2Department of Ophthalmology, University of California, Los Angeles, CA, USA 90095
3Doheny Eye Institute, Pasadena, CA, USA 91103
4Molecular, Cellular, and Integrated Physiology Interdepartmental PhD Program, University of California, Los Angeles, CA, USA 90095
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Mahesh Agarwal
2Department of Ophthalmology, University of California, Los Angeles, CA, USA 90095
3Doheny Eye Institute, Pasadena, CA, USA 91103
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Nikolaos Matisioudis
3Doheny Eye Institute, Pasadena, CA, USA 91103
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Timothy S. Kern
5Department of Ophthalmology, University of California, Irvine, CA, USA 92697
6Gavin Herbert Eye Institute, University of California, Irvine, CA, USA 92697
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Kaustabh Ghosh
1Department of Bioengineering, University of California, Riverside, CA, USA 92521
2Department of Ophthalmology, University of California, Los Angeles, CA, USA 90095
3Doheny Eye Institute, Pasadena, CA, USA 91103
4Molecular, Cellular, and Integrated Physiology Interdepartmental PhD Program, University of California, Los Angeles, CA, USA 90095
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  • ORCID record for Kaustabh Ghosh
  • For correspondence: ghoshk@ucla.edu
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Article Information

doi 
https://doi.org/10.1101/2022.08.31.505952
History 
  • September 3, 2022.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Sathishkumar Chandrakumar1,2,3,
  2. Irene Santiago Tierno2,3,4,
  3. Mahesh Agarwal2,3,
  4. Nikolaos Matisioudis3,$,
  5. Timothy S. Kern5,6 and
  6. Kaustabh Ghosh1,2,3,4,#
  1. 1Department of Bioengineering, University of California, Riverside, CA, USA 92521
  2. 2Department of Ophthalmology, University of California, Los Angeles, CA, USA 90095
  3. 3Doheny Eye Institute, Pasadena, CA, USA 91103
  4. 4Molecular, Cellular, and Integrated Physiology Interdepartmental PhD Program, University of California, Los Angeles, CA, USA 90095
  5. 5Department of Ophthalmology, University of California, Irvine, CA, USA 92697
  6. 6Gavin Herbert Eye Institute, University of California, Irvine, CA, USA 92697
  1. ↵#Address all correspondence to: Kaustabh Ghosh, Ph.D., Department of Ophthalmology, University of California, Los Angeles, Doheny Eye Institute, 150 N. Orange Grove Blvd., Pasadena, CA 91103, phone: 323-342-7164 ; fax: 323-342-6688, email: ghoshk{at}ucla.edu
  • ↵$ Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104

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Posted September 03, 2022.
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Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S. Kern, Kaustabh Ghosh
bioRxiv 2022.08.31.505952; doi: https://doi.org/10.1101/2022.08.31.505952
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Lysyl oxidase-dependent subendothelial matrix stiffening promotes RAGE-mediated retinal endothelial activation in diabetes
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S. Kern, Kaustabh Ghosh
bioRxiv 2022.08.31.505952; doi: https://doi.org/10.1101/2022.08.31.505952

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