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The Entorhinal-DG/CA3 Pathway in the Medial Temporal Lobe Retains Visual Working Memory of a Simple Surface Feature

View ORCID ProfileWeizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem Zaghloul, Weiwei Zhang
doi: https://doi.org/10.1101/2022.08.31.506098
Weizhen Xie
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda MD
2Department of Psychology, University of California, Riverside
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  • ORCID record for Weizhen Xie
  • For correspondence: weizhen.xie@nih.gov weiwei.zhang@ucr.edu
Marcus Cappiello
2Department of Psychology, University of California, Riverside
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Michael A. Yassa
3Center for the Neurobiology of Learning and Memory, School of Biological Sciences, University of California, Irvine
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Edward Ester
4Department of Psychology, University of Nevada, Reno
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Kareem Zaghloul
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda MD
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Weiwei Zhang
2Department of Psychology, University of California, Riverside
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  • For correspondence: weizhen.xie@nih.gov weiwei.zhang@ucr.edu
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Abstract

Classic models consider working memory (WM) and long-term memory as distinct mental faculties that are supported by different neural mechanisms. Yet, there are significant parallels in the computation that both types of memory require. For instance, the representation of precise item-specific memory requires the separation of overlapping neural representations of similar information. This computation has been referred to as pattern separation, which can be mediated by the entorhinal-DG/CA3 pathway of the medial temporal lobe (MTL) in service of long-term episodic memory. However, although recent evidence has suggested that the MTL is involved in WM, the extent to which the entorhinal-DG/CA3 pathway supports precise item-specific WM has remained elusive. Here, we combine an established orientation WM task with high-resolution fMRI to test the hypothesis that the entorhinal-DG/CA3 pathway retains visual WM of a simple surface feature. Participants were retrospectively cued to retain one of the two studied orientation gratings during a brief delay period and then tried to reproduce the cued orientation as precisely as possible. By modeling the delay-period activity to reconstruct the retained WM content, we found that the anterior-lateral entorhinal cortex (aLEC) and the hippocampal DG/CA3 subfield both contain item-specific WM information that is associated with subsequent recall fidelity. Together, these results highlight the contribution of MTL circuitry to item-specific WM representation.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Revised figure.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 21, 2022.
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The Entorhinal-DG/CA3 Pathway in the Medial Temporal Lobe Retains Visual Working Memory of a Simple Surface Feature
Weizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem Zaghloul, Weiwei Zhang
bioRxiv 2022.08.31.506098; doi: https://doi.org/10.1101/2022.08.31.506098
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The Entorhinal-DG/CA3 Pathway in the Medial Temporal Lobe Retains Visual Working Memory of a Simple Surface Feature
Weizhen Xie, Marcus Cappiello, Michael A. Yassa, Edward Ester, Kareem Zaghloul, Weiwei Zhang
bioRxiv 2022.08.31.506098; doi: https://doi.org/10.1101/2022.08.31.506098

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